Development and Validation of Spectrophotometric Method for the Determination of Perindopril Erbumine in Bulk Dosage Form
Journal Title: American Journal of Phytomedicine and Clinical Therapeutics - Year 2013, Vol 1, Issue 1
Abstract
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of perindopril erbumine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 213nm. The developed method was validated with respect to accuracy, linearity, precision, limit of detection, limit of quantification and Sandell’s sensitivity. Beers law was obeyed in the concentration range of 4-16µg/ml having line equation Y=0.01350X+0.05879 with correlation coefficient of 0.998. Results of the analysis were validated statistically.
Authors and Affiliations
Ratnaparkhi Mukesh, Patil Pradeep, Jagadale Sachin
Effect of Gymnema Sylvestre on the Pharmacokinetics and Pharmacodynamics of Gliclazide in Diabetic Rats
Gymnema sylvestre (GS) and gliclazide both selectively promote insulin release. GS stimulate ß-cell function, increase ß-cell number, increases the enzyme activity responsible for glucose uptake and utilization. Gl...
Rationale Behind the Use of Temnocalyx Obovatus Roots as Antivenins Against Snakebites in Primary Health Care
Worldwide snakebites are a health hazard. In recent years there has been an increased interest in alternative therapeutics especially those derived from plants. The aim of the present study was to provide a rationa...
Development and Validation of a LC-MS/MS Method for the Determination of Erlotinib in Sprague Dawley Rat Serum and its Application to Pharmacokinetic Study
A novel bio-analytical method was developed and validated for the quantitative determination of erlotinib in rat serum by using the liquid-liquid extraction extraction chromatography and tandem mass spectrometric d...
Preparation and Optimization of Glimepiride Multiparticulate System Using Novel Liquid Layering Technique
Background and the purpose of the study: Multiparticulates by liquid layering process has advantages of producing homogenous small drug loaded units, high reliability and the possibility of applying the successive...
Antinociceptive Potential of Terminalia Catappa (Indian Almond) Leaves in Swiss Albino Rat
Terminalia catappa (almond) is a combretaceous plant whose leaves are widely used as a folk medicine for treatments of dermatitis, hepatitis, inflammatory disease, diabetes and other disease. The Antinociceptive a...