DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND LORNOXICAM IN BULK AND TABLET DOSAGE FORM
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
A simple and sensitive spectrophotometric method has been developed for simultaneous determination of Paracetamol and Lornoxicam in a binary mixture. In the proposed method, the absorbances were measured at 257.0 nm and 287.0 nm corresponding to the absorbance maxima of Paracetamol and Lornoxicam in 0.1 N Sodium Hydroxide respectively. Linearity range was observed in the concentration range of 5-30 μg/ml for Paracetamol and 2-10 μg/ml for Lornoxicam. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 257.0 nm and 287.0 nm and solving the simultaneous equation. Developed method was applied to laboratory mixture and its marketed formulation. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise.
Authors and Affiliations
K. C. Bhavsar
Keywords
Related Articles
- EP ID EP139618
- DOI -
- Views 140
- Downloads 0
HEPATOPROTECTIVE ACTIVITY OF SILYMARIN FLOATING DRUG DELIVERY SYSTEM AGAINST ANTI TUBERCULOSIS DRUG
A Gastroretentive floating controlled drug delivery system containing Silymarin was prepared in the form of tablets and evaluated for its processing parameters, in vitro release in 0.1 N HCl. Eight formulations were prep...
FORMULATION STUDIES ON CYCLODEXTRIN COMPLEXES OF MELOXICAM
b-Cyclodextrin (b-CD) and HP-b-Cyclodextrin (HP-b-CD) inclusion complexes of meloxicam (M) exhibited higher dissolution rates and dissolution efficiency values than the corresponding uncomplexed drug. The feasibility of...
PHARMACOEPIDEMIOLOGY: A COMPLEMENT TO THERAPEUTIC TRIALS
Pharmacoepidemiology as a discipline goes beyond epidemiologic studies of drug-related topics. Some topics receiving much attention in Pharmacoepidemiology get little in traditional epidemiology, where as others included...
FORMULATION OF METFORMIN HYDROCHLORIDE MATRIX TABLETS BY SINTERING TECHNIQUE AND ITS EVALUATION
Metformin hydrochloride is a biguanide, which is used as an oral hypoglycemic agent. It is a white crystalline hygroscopic drug used as an antidiabetic agent specifically for type-2 diabetes mellitus. When given, a divid...
COMPUTER-AIDED DESIGN AND SCREENING OF CHALCONES AS<br /> NOVEL PPAR GAMMA AGONISTS
Type II diabetes mellitus is a chronic metabolic disorder and PPARs were found to be better targets in lowering glucose levels. Here, we report a computer-aided drug design approach to screen various chalcones, designed...