Development and Validation of Various UV Spectrophotometric Methods for the Estimation of Famciclovir in Bulk and its Formulation
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 2
Abstract
Abstract:The present paper described about the development and validation of three different simple, sensitive, rapid, accurate and economical UV Spectrophotometric methods. The developed methods were used for the quantitative estimation of famciclovir in bulk drug and its pharmaceutical dosage form. UV 1800 double beam UV Visible Spectrophotometer with a pair of 10mm path length matched quartz cells were used for the study. Method A (Borate buffer pH9), Method B (0.1N NaOH) Method C (Phosphate buffer pH4) and Method D (Phosphate buffer pH 7) were developed for estimation of famciclovir by zero-order and first-order derivative. Beer’s law is valid in the concentration range of 10-80 μg/mL and 10-90 μg/mL respectively and the correlation coefficient was found to be 0.999. The percentage recoveries were found to be 98-102%. The relative standard deviation was found to be <2%. LOD&LOQ were estimated. The statistical analysis proves that the methods are reproducible and selective for the routine analysis of famciclovir in bulk and its pharmaceutical dosage form. Keywords:Famciclovir, Spectrophotometer, method development, validation.
Authors and Affiliations
Sumanta Mondal, Prasenjit Mondal
Keywords
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