Development of an Antihypertensive Loaded Solid Lipid Nanoparticle
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2024, Vol 8, Issue 2
Abstract
Solid lipid nanoparticles were prepared by using the solvent evaporation method. The prepared solid lipid nanoparticles of felodipine from different batches were weighed accurately and filled into appropriate-sized capsules for further evaluation. The prepared nanoformulation was tested in vitro for drug entrapment efficiency found to be 97-99% for the formulation with soya lecithin and glyceryl mono-stearate and percentage yield. The results of the in vitro drug release study for all formulations performed at gastric pH 1.2 indicated that the drug was released in an immediate manner within 60 minutes, which could be due to a burst effect or a faster rate of drug release due to smaller particle size SLN13 the concentration of Glycerol Monosterate- 576.522mg and Poloxamer 188. In vitro release data from standardised nanoformulations was fitted to various release kinetics models for the drug release mechanism. The optimised formulation demonstrated improved drug release and entrapment efficiency, and in vitro release data were fitted to various kinetic models to better understand the drug release mechanism. In vitro assay results were ranged between 76.5 to 96%, Zeta potential -40.75 ± 2.33 (mV) ± SD, entrapment efficiency 99.32. Accelerated stability studies for standardised nanoformulations were performed for 6 months in accordance with standard ICH guidelines, and no appreciable changes in the physical appearance, drug content, and in vitro drug release rates of the nanoformulations were observed. As a result of the study's evidence, it is concluded that felodipineloaded solid lipid nanoparticles are the best choice for hypertension.
Authors and Affiliations
Amith B*, Basavaraj BV and Nikitha S
Keywords
Related Articles
- EP ID EP751955
- DOI 10.23880/oajpr-16000314
- Views 38
- Downloads 0
Assessment of Self-Medication and Disease Awareness about Migraine in Local Community of Multan, Pakistan
Background: Self-Medication and Poor disease awareness of Migraine is the furthermost public well-being concern in many countries, as well as in Pakistan. Thus considering the current epidemiological evidence about that...
Nano-Lamination - A New Frontier in Manufacturing
Nano-Lamination is a newly emerging technology of nanotechnology. With its vast applications in almost in every discipline of life, it is hoped that this may change the way we live our life. Though it is new introduced...
Application of Plant Based Natural Polymer in Drug Delivery System: A Critical Overview
Several natural polymers have been used for a variety of biomedical applications including drug targeting, pharmaceutical preparations, drug delivery systems, prosthetics, and tissue engineering scaffolds. Natural polym...
Antimicrobial Potential: Herbal Cream of Salsola Baryosma Roots
Salsola baryosma, native to Punjab, Baluchistan, Sindh areas of Pakistan, has folk use of topical anti microbial effects in crude form in Cholistan desert, Pakistan. In present study this activity was used to prepare cre...
Benzimidazole:- A Versatile Moiety
Benzimidazole is a promising nitrogen-containing nucleus with extensive pharmacological activity, some of which are listed in this article, such as antiprotozoal, anthelmintic, antipsychotic, antiparasitic, antifungal,...