Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles
Journal Title: The AAPS Journal - Year 2009, Vol 11, Issue 3
Abstract
Microparticles of DSCG alone or with 90% w/w PVA where prepared and characterised as described previously (5,6). Briefly, DSCG was spray dried under optimised conditions to produce a yield of microparticles with desired characteristics suitable for pulmonary inhalation. Particle sizing, imaging, aerosolisation performance and in vitro release studies were the key assessments performed. Although previous studies focussed on a series of PVA concentrations, for this study, the two extremes were chosen: DSCG with 0% PVA and DSCG with 90% w/w. They will be referred to as DSCG and DSCG/PVA formulations, respectively.
Authors and Affiliations
Rania O. Salama, Leigh Ladd, Hak-Kim Chan, Daniela Traini, Paul M. Young
Keywords
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