Development of an Ointment Formulation Using Hot-Melt Extrusion Technology
Journal Title: AAPS PharmSciTech - Year 2016, Vol 17, Issue 1
Abstract
Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.
Authors and Affiliations
Ajinkya M. Bhagurkar, Muralikrishnan Angamuthu, Hemlata Patil, Roshan V. Tiwari, Abhijeet Maurya, Seyed Meysam Hashemnejad, Santanu Kundu, S. Narasimha Murthy, Michael A. Repka
Keywords
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- EP ID EP682152
- DOI 10.1208/s12249-015-0453-3
- Views 102
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