Development of composition and technology of hard gelatinous capsules of hepatoprotective and immunomodulating action
Journal Title: Фармацевтичний журнал - Year 2014, Vol 1, Issue 1
Abstract
It is proven by modern clinical medicine, that there is violation of one from liver functions at it’s diseases, in particular synthesis of immunoproteins, that results in violation of humoral chain of immunity. Therefore a problem of creation of medication of the combined action, hepatoprotective and immunomodulating, is actual for practical pharmacy. The choice of medicinal form and technology development of medicine of hepatoprotective and immunomodulating action have been carried out in this work. Natural compounds were as objects of research: plant protein of sunflower and immunomodulator (мiх-factor). Hard gelatinous capsules have been chosen as a rational medicinal form. Powder of sunflower plant protein as a component with a immunomodulating effect and МIХ-factor as the wetting agent and immunomodulating and hepatoprotective component have been used at the obtaining of granulate by the method of wet granulation. It has been educed in accordance with methods of SPhU at the obtained granulate research, that on technological descriptions a granulate is subject to the encapsulation without addition of auxiliary substances. The granulate encapsulation have been carried out in a capsule N 4 with a middle capacity 0.21 ml by means of semi-automatic laboratory capsule machine.
Authors and Affiliations
А. А. Manscy
Keywords
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