DEVELOPMENT OF FROVATRIPTAN SUCCINATE MICROEMULSION FOR NASAL DELIVERY: OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 4
Abstract
Objective: The main objective of the present research work was to develop, optimize, and characterize microemulsion (ME) of frovatriptan succinate to improve brain transport. Methods: The pseudoternary phase diagrams were constructed for ME formulations composed of Capmul MCM, Cremophor EL, and propylene glycol. Frovatriptan succinate-loaded ME was optimized by simplex lattice design having the concentration of oil, surfactant, and cosurfactant representing three apex points on the triangle. These were taken as independent variables and percentage drug release as a response variable. All developed batches of ME were characterized for in vitro tests, histopathology study, and pharmacokinetics in Swiss albino rats. Results: Clear MEs were obtained. F5 having particle size – 142.0 nm, zeta potential – 17.7–−7.8 mv, refractive index – 1.38±0.20, drug content – 98.24±0.20%, and drug diffused through dialysis membrane – 85% was the optimized batch. Drug permeation through the nasal mucosa of F5 in the ex vivo study was found to be 82.32%. Histopathology microscopic study has shown that F5 does not cause any irritation and structural changes in sheep nasal mucosa. The pharmacokinetic parameters were determined after nasal and oral administration of F5. For brain tissue, after nasal administration were Cmax181±1.51 ng/ml, Tmax – 2±1.01, area under curve (AUC)0−6 – 390.0±2.08 ng.h/ml. The AUC0−6 attained by nasal ME was 3.29 times greater than oral solution. Drug targeting index of frovatriptan succinate was 2.06. This was found satisfactory. Conclusion: Microemulsion of said composition was found to be enhancing delivery of frovatriptan succinate to brain tissues through nasal route.
Authors and Affiliations
UPENDRA C GALGATTE , PRAVIN D CHAUDHARI
Keywords
Related Articles
- EP ID EP604694
- DOI -
- Views 125
- Downloads 0
EVALUATION OF ANTI-ULCER ACTIVITY OF THE ETHANOLIC EXTRACT OF PHYLLANTHUS URINARIA IN EXPERIMENTAL ANIMALS
Objective: The objective of this study is to investigate the antiulcer activity of the ethanolic extract of Phyllanthus urinaria (EEPU). Methods: In vivo anti-ulcer activity of EEPU was evaluated in the present study at...
KNOWLEDGE AND PERCEPTIONS OF SELF-MEDICATION PRACTICES IN AN URBAN COMMUNITY
Objective: This study was conducted with the aim to assess the knowledge and attitude of self-medication practices among the residents of an urban community. Methods: A cross-sectional, observational study was conducted...
EFFECT OF PRE EXAMINATION STRESS ON OLFACTORY SENSITIVITY IN COLLEGE STUDENTS.
 Objective: The present study was undertaken to assess the effect of pre-examination stress on olfactory sensitivity in college students.Methods: A total of 80 apparently healthy males and females were included in the s...
AN ETHNOBOTANICAL STUDY OF WILD MEDICINAL PLANTS USED BY MIGRATORY SHEPHERDS – A TRIBAL COMMUNITY OF WESTERN HIMALAYAS
Objectives: Migratory shepherds of Kinnaur, Shimla, and Sirmaur districts in Himachal Pradesh of the western Himalayas have rich traditional knowledge of medicinal plants and its uses, in this respect; an ethnobotanical...
DEVELOPMENT AND VALIDATION OF A HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FOR THE DETERMINATION OF TERBUTALINE SULFATE, BROMHEXINE HYDROCHLORIDE, AND ETOPHYLLINE IN PHARMACEUTICAL DOSAGE FORM
Objective: The study aimed to development and validation of simple, precise, and reliable high-performance thin-layer chromatography (HPTLC) for the determination of terbutaline sulfate (TBS), bromhexine hydrochloride (B...