Development of gel composition and technology based on pyrimidine substance

Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 9

Abstract

Background: This work was conducted in the framework of quality by design project involving the production of a pharmaceutical gel. Preliminary work included the identification of the quality target product profiles from historical values for previously laboratory batches, which were used to construct a D-optimal experimental design. Fungal disease of mycoses has long been known, since the days of antiquity. Our research gel high pharmacological effect (antifungal) in comparison with the drugs “Flucytosine” and “Fucis”. Aims and Objectives: The purpose of this study is to develop the optimal composition and rational gel technology under the conventional name “Antiсandid” on the basis of the substance piperidinylethanone with an antifungal effect. Materials and Methods: Thermogravimetric analysis and rotational viscometry, which affect the process of the formation of carbopol, were taken. Based on the physicochemical properties and technological properties of the gel, an optimal solvent system is selected that corresponds to the maximum solubility of the drug substances and ensures polymer swelling. At the same time, the materials dimexide (DMSO), propylene glycol (PG), carbol-floor, and triethanol were taken into account, which improve the process of solubility and gelling. Results: The results were obtained, which, when the active substance is administered in the dissolved state, is the most therapeutic effect on the gel base. At the same time, active pharmaceutical ingredients (APIs) were dissolved in different solvents with gradual heating. The ratio of solvents DMSO-PG-water (1:4:1) at which the developed dosage form will be more structured, stable, and thixotropic is established. Conclusion: Fungal skin diseases are one of the most frequently discussed problems in various dermatological forums and in the pages of scientific journals. The relevance of this topic is determined by the high prevalence of this pathology, which, according to the literature, accounts for 37-42% of all skin diseases. The results of the studies on the study of the microbiological, physicochemical properties of APIs, and carbopol Ultrez 20 for the development of optimal composition are taken into account. It was found that the gel model with an active substance content of 3% is more effective and has high antifungal activity.

Authors and Affiliations

Uldan B Derbisbekova, Ubaidilla M Datkhayev, Khairolla D Rakhimov, Irina A Zhuravel, Balzhan G Makhatova, Tansholpan B Zabynbekova

Keywords

Related Articles

Effect of premenstrual stress on reaction time of 18-20 years age group

Background: The premenstrual syndrome is a recurrent, variable cluster of trouble some ill-defined symptoms and signs that develop during the 10 days before the onset of menses and subside when menstruation occurs. There...

Lifestyle risk factors for coronary artery disease among young male patients of urban and rural Dakshina Kannada - A cross-sectional study

Background: There has been an increase in morbidity and mortality due to coronary artery disease (CAD) in developing countries due to multiple risk factors. India’s concern is not only the high burden of CAD but also its...

Comparative study of response to experimental cold pain in dysmenorrheic and nondysmenorrheic women

Background: There has been keen research interest into the gender differences in tolerance of pain sensation. Dysmenorrheic pain is common among women of reproductive age group. Assessment of pain perception will result...

Depression, anxiety, and stress levels in patients with type 2 diabetes mellitus

Background: Diabetes is a lifestyle disorder where there is an increase in the blood glucose levels which can be observed. Being diabetic is stressful and being stressful worsens diabetes. Hence, management of stress is...

 Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation

 Background: Kidney forms the main controlling organ in sustaining homeostasis and, thus, is vulnerable to toxicity by xenobiotics. Aims and Objective: To evaluate the possible protective effects of the citrus flav...

Download PDF file
  • EP ID EP290989
  • DOI 10.5455/njppp.2017.7.0518412062017
  • Views 82
  • Downloads 0

How To Cite

Uldan B Derbisbekova, Ubaidilla M Datkhayev, Khairolla D Rakhimov, Irina A Zhuravel, Balzhan G Makhatova, Tansholpan B Zabynbekova (2017). Development of gel composition and technology based on pyrimidine substance. National Journal of Physiology, Pharmacy and Pharmacology, 7(9), 901-906. https://europub.co.uk/articles/-A-290989