Development of gel composition and technology based on pyrimidine substance

Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 9

Abstract

Background: This work was conducted in the framework of quality by design project involving the production of a pharmaceutical gel. Preliminary work included the identification of the quality target product profiles from historical values for previously laboratory batches, which were used to construct a D-optimal experimental design. Fungal disease of mycoses has long been known, since the days of antiquity. Our research gel high pharmacological effect (antifungal) in comparison with the drugs “Flucytosine” and “Fucis”. Aims and Objectives: The purpose of this study is to develop the optimal composition and rational gel technology under the conventional name “Antiсandid” on the basis of the substance piperidinylethanone with an antifungal effect. Materials and Methods: Thermogravimetric analysis and rotational viscometry, which affect the process of the formation of carbopol, were taken. Based on the physicochemical properties and technological properties of the gel, an optimal solvent system is selected that corresponds to the maximum solubility of the drug substances and ensures polymer swelling. At the same time, the materials dimexide (DMSO), propylene glycol (PG), carbol-floor, and triethanol were taken into account, which improve the process of solubility and gelling. Results: The results were obtained, which, when the active substance is administered in the dissolved state, is the most therapeutic effect on the gel base. At the same time, active pharmaceutical ingredients (APIs) were dissolved in different solvents with gradual heating. The ratio of solvents DMSO-PG-water (1:4:1) at which the developed dosage form will be more structured, stable, and thixotropic is established. Conclusion: Fungal skin diseases are one of the most frequently discussed problems in various dermatological forums and in the pages of scientific journals. The relevance of this topic is determined by the high prevalence of this pathology, which, according to the literature, accounts for 37-42% of all skin diseases. The results of the studies on the study of the microbiological, physicochemical properties of APIs, and carbopol Ultrez 20 for the development of optimal composition are taken into account. It was found that the gel model with an active substance content of 3% is more effective and has high antifungal activity.

Authors and Affiliations

Uldan B Derbisbekova, Ubaidilla M Datkhayev, Khairolla D Rakhimov, Irina A Zhuravel, Balzhan G Makhatova, Tansholpan B Zabynbekova

Keywords

Related Articles

Use of scenarios to increase the effectiveness of lecture-based sessions in pharmacology

Background: The current system of pharmacology teaching in India is mostly through lectures, which is a teacher oriented, monotonous and passive way of learning and does not encourage higher order thinking or ability to...

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development...

Blood pressure pattern and hypertension rates among selected tribal population of Kerala

Background: Non-communicable diseases such as hypertension, diabetes, and cancer have replaced communicable diseases as the leading cause of mortality in most parts of the world including India. Hypertension is a major p...

Comparative study of variations in blood pressure and heart rate among normotensive patients and hypertensive patients receiving angiotensin receptor blockers during surgery under spinal anesthesia

Background: Hypotension is the most common complication associated with spinal anesthesia and more common in patients with a history of hypertension. Regular use of antihypertensive medications can prevent this effect. H...

A comparative study on coagulation profile and neutrophil-lymphocyte ratio in pregnancy-induced hypertension

Background: Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. It is associated with alteration of hematological profile,...

Download PDF file
  • EP ID EP290989
  • DOI 10.5455/njppp.2017.7.0518412062017
  • Views 84
  • Downloads 0

How To Cite

Uldan B Derbisbekova, Ubaidilla M Datkhayev, Khairolla D Rakhimov, Irina A Zhuravel, Balzhan G Makhatova, Tansholpan B Zabynbekova (2017). Development of gel composition and technology based on pyrimidine substance. National Journal of Physiology, Pharmacy and Pharmacology, 7(9), 901-906. https://europub.co.uk/articles/-A-290989