Development of the methodological approach of obtaining preparations based on solid dispersions
Journal Title: ScienceRise: Pharmaceutical Science - Year 2018, Vol 0, Issue 4
Abstract
<p>Nowadays, the innovative direction of pharmaceutical development is the application of methods to increase the biopharmaceutical efficiency and safety of the use of already existing APIs, including method of incorporating them into solid dispersions in which the substance molecules are included in the supramolecular formations by forming non-covalent bonds by excipients. Today, the preparation of solid dispersions is considered as the most effective way of increasing oral bioavailability, in which dissolution of the carrier facilitates the release of API with its rapid solubilization. According to the literature, it is established that today there is only an empirical approach to obtaining solid dispersions.</p><p><strong>The aim</strong> of the work was the formulation of the main approaches to the development of preparations on the basis of solid dispersions, taking into account the current trends in the development of the composition and technology of preparations with sparingly soluble active pharmaceutical ingredients.</p><p><strong>Materials and methods.</strong> To develop a methodological approach, external situational content analysis of applied methods for increasing the bioavailability of active pharmaceutical ingredients used in the manufacture of solid dosage forms was used.</p><p><strong>Results.</strong> In the course of accomplishing this goal, a classification of the types of solid dispersions was proposed depending on the structure and method of production, an algorithm was developed for choosing a method for obtaining a solid dispersion, taking into account the physico-chemical properties of the active pharmaceutical ingredients, which can be used in the technological process to increase their bioavailability. Critical components were also found in the development of solid dispersions.</p><p><strong>Conclusions.</strong> Taking into account the physicochemical properties of the active pharmaceutical ingredients, was chosen an algorithm for selecting a method for preparing solid dispersions that can be used in the process to improve their bioavailability. Based on the results of the analysis of the literature data and our own research of the physico-chemical characteristics of the active pharmaceutical ingredients and excipients, type of the solid dispersion structure, the type of solvent and carrier, a methodological approach to the preparation of solid dispersions is proposed, the use of which will optimize the development of solid dosage forms</p>
Authors and Affiliations
Inna Kovalevska, Olena Ruban
Keywords
Related Articles
- EP ID EP526841
- DOI 10.15587/2519-4852.2018.140756
- Views 149
- Downloads 0
The substantiation of the selection of medicinal plants and their rational application in diseases of the hepatobiliary system
<p><strong>Aim of the work</strong>. The aim of the work was to develop methodological approaches to justify the selection of medicinal plants and phytopreparations for diseases of the hepatobiliary system and to determi...
Determination of the need for medicinal products of plant origin used for treating cardiovascular diseases
<p><strong>Aim</strong><strong> </strong><strong>of</strong><strong> </strong><strong>the</strong><strong> </strong><strong>study</strong><strong> </strong>is to determine the need for medicinal products of plant origin...
Analysis of the Ukrainian market of parapharmaceuticals for prevention of keloid scars
<p>An analysis of the anti-keloid parapharmaceuticals (AKPF) market, for preventing the formation of keloid scar (KS) and providing the population with affordable drugs is an urgent issue at this time. Doctors have not y...
Study of superoxide- and NO-dependent protective mechanisms of N-acetylcysteine and losartan in ratʼs aorta and liver under streptozoticin-induced type 1 diabetes mellitus
<p><strong>Aim.</strong> The aim of the research was to investigate superoxide- (SR) and NO-dependent mechanisms of action of N-acetylcysteine (NAC) and losartan (LOS) in aorta and liver of rats with type 1 diabetes mell...
Вивчення стероїдних сполук у сировині канни садової
<p><strong>Мета. </strong>Ідентифікація та визначення кількісного вмісту стероїдних сполук у коренях, кореневищах, листках та квітках канни садової.</p><p><strong>Методи дослідження. </strong>Ідентифікацію стероїдних спо...