DEVELOPMENT OF THERMOGELLING HYDROGELS BASED ON A POLOXAMER 407 / CHITOSAN MIXTURE FOR SKIN APPLICATION
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 10
Abstract
Aim: The objective of this study was to develop Poloxamer 407/Chitosan mixtures. Thiolated or not for the treatment of certain skin ulcers like Buruli Ulcer after having synthesized 2-Iminothiolane or Thiobutylamidine (TBA), intermediate for the synthesis of thiolated chitosan. Material and méthods: Synthesis of TBA was done in two steps: synthesis of 4 (acetylthio)-butyronitrile by using thioacetic acid and 4-bromobutyronitrile; synthesis of 2-Iminothiolane HCl by using 4 (acetylthio)-butyronitrile. Modification of chitosan has been made by using 2 Iminithiolane and some chitosans. The poloxamer solutions were prepared in 0,1M acetic acid, and demineralised water. Results: The preparations had a good homogeneity and the gelling temperature of the F127/Chitosan mixtures is essentially controled by poloxamer. Conclusion: This study has shown that the gelation process is favoured by an increase in the concentration of F127 and is significantly disadvantaged by 0,1M acetic acid. The gelling temperature of the F127 / Chitosan mixtures is essentially controlled by the poloxamer.
Authors and Affiliations
Dr. Lia G. J. A.
Keywords
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