Development of UV-Spectrophotometric Method for the Determination of Imatinib Mesylate (ITM) In Bulk and Formulation
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2016, Vol 4, Issue 2
Abstract
A simple, rapid, precise and highly selective spectrophotometric method was developed for estimation of imatinib in tablet dosage form.this method, involves the measurement of absorbances of imatinib at the wavelength of 255.20nm. distilled water was used as solvent. linearity was observed in the concentration range of 2-12μg/ml for imatinib. the accuracy of the method was confirmed by recovery studies of tablet dosage forms and was found to be 101.2% for imatinib.the method showed good reproducibility and recovery with%rsd lessthan 6. the lod of imatinib was found to be 0.066μg/ml and loq of imatinib was found to be 0.2μg /ml.thus the proposed method was found to berapid,specific, precise, accurate and cost effective quality control tool for the routine analysis of imatinib in bulk and tablet dosage form.
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