DEXAMETHASONE, THE POOR MAN'S DRUG: AN ALTERNATIVE TO METHYLPREDNISOLONE IN OPTIC NEURITIS
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 7
Abstract
Aim: To assess the visual function outcome and response of intravenous dexamethasone in the treatment of optic neuritis in a tertiary health care centre. Materials and Methods: Study included 30 patients of acute optic neuritis presenting within eight days of onset and with visual acuity less than 20/60 in the affected eye. Patients received intravenous dexamethasone 100 mg in 250 ml of 5% dextrose over 1-2 hours daily, for three consecutive days[7] . Parameters tested were pupillary reactions, visual acuity, fundus ndings, color vision, contrast sensitivity and visual elds for all patients at presentation and follow-up over a period of 1 year and results compared with standard pattern of outcome already laid down by randomised controlled trials such as ONTT(Optic Neuritis Treatment Trial) which used intravenous methylprednisolone 250 mg/six-hourly for three days followed by oral prednisolone for 11 days for treatment of optic neuritis and proved its efcacy. Results: Improvement in visual acuity was statistically signicant for distance on day 3 ( P =0.000434 ) and for near vision on day 3 ( P =0.000045); improvement in color vision was statistically signicant on day 3 ( P =0.000143) . Signicant improvement in RAPD,contrast sensitivity and visual elds were seen by 1 month (p<0.05). No serious side effects were observed. At one year, 78.12% (25 out of 32) eyes had visual acuity ≥ 20/40. Conclusion: Intravenous dexamethasone is a cost effective alternative to methylprednisolone treatment for optic neuritis.
Authors and Affiliations
Dr Sharmistha Behera, Dr Bidisha Mahapatra, Dr K. C. Tudu
Keywords
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