Diabetes – a therapeutic roadmap
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2014, Vol 6, Issue 5
Abstract
Diabetes is a condition in which the body does not make enough insulin or the body cells cannot use insulin properly. Insulin is a hormone that helps the body use glucose (sugar) for energy. Without insulin, glucose (the body's main energy source) builds up in the blood, resulting in high blood sugar. There were an estimated 40 million persons with diabetes in India in 2007 and this is no is predicated to rise to 70 million people in 2025.Due to this sheer number economic burden due to diabetes in India is amongst highest in the world. Type 2 diabetes is due to progressive insulin resistance is increase in insulin secretion by pancreatic cell causing hyperinsulinaemia. Insulin resistance is a characteristic feature of most of patients with type 2 diabetes mellitus. The complications of diabetes are preliminary due to high level of blood glucose and also poor glycemic control. Short terms complications happen very quickly and long term complications are comprises of microvascular and macrovascular complications. Prediabetes is most important term and it provides information of those metabolic states that occurs when blood glucose levels are high but remain below level that is established for clinical diagnosis. Prediabetes is the term which includes impaired fasting glucose or impaired glucose intolerance. The therapeutic consequences to treat T1DM and T2DM are proper nutrition, exercise, education and proper pharmacological therapy. In pharmacological therapy many of drugs or medications includes such as Secretagogues, Metformin Thiazolidinediones, alpha glycosidase inhibitor.
Authors and Affiliations
Shirke Madhuri A. , Magdum Chandrakant, S. and D’isouza John, I.
Keywords
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