Diabetes Mellitus in Thalassaemia Major Patients: A Report from the Southeast of Iran
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Diabetes Mellitus (DM) represents a major concern in Thalassaemia Major (TM) patients. Aim: The present study was conducted to evaluate the frequency of Impaired Fasting Glucose (IFG) and DM in TM patients in Southeast of Iran. Materials and Methods: Fasting Blood Glucose (FBS) was determined using fasting blood samples in 148 TM patients. Demographical data was collected by a questionnaire. Clinical and laboratory variables including cell blood counts, pretransfusion Haemoglobin (Hb) level, and five-year ferritin were extracted from medical records. Statistical analysis was performed in SPSS19.0 software using chi-square, student t-test and logistic regression. Results: Females and males comprised 83 (56.1%) and 65 (43.9%) subjects respectively. The mean age and mean fiveyear ferritin were 17.3±6.1 year-old and 5060.6±2395 ng/ml respectively. Overall, 39 (26.4%) patients had IFG, while 13 (8.8%) were diagnosed with DM. Significant differences were identified in the mean age, volume of transfused blood per occasion, and mean five-years ferritin between the patients with IFG or DM and the patients with normal fasting glucose level. Patients with age >25-year-old had an increased risk of both IFG (OR=4.7,95% CI: 1.3-17, p=0.01) and DM (OR= 7.1, 95% CI: 1-49.2, p=0.04). In addition, splenectomized patients showed a higher risk for IFG (OR=4.3, 95% CI: 1.5-12.1, p=0.005), and ferritin value >6000 ng/ml were associated with an elevated risk of DM (OR=7, 95% CI: 0.8-60.1, p=0.07). Conclusion: Our results indicated that higher age, mean fiveyears ferritin, volume of blood transfused per occasion, as well as splenectomy were risk factors of IFG and DM in TM patients.
Authors and Affiliations
Ali Bazi, Javad Sharifi- Rad, Daryoush Rostami, Omolbanin Sargazi-Aval, Amin Safa
Keywords
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- EP ID EP341157
- DOI 10.7860/JCDR/2017/24762.9806
- Views 107
- Downloads 0
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