Diagnosis Dini Tuberkulosis pada Kontak Serumah dengan Penderita Tuberkulosis Paru melalui Deteksi Kadar IFN-γ
Journal Title: Kesmas: National Public Health Journal - Year 2014, Vol 9, Issue 1
Abstract
Tuberculosis remains a global problem. In 2012, Indonesia has the third biggest tuberculosis cases in the world. The national target in Case Detection Rate for tuberculosis in 2012 was 70%, whereas Jawa Tengah reached only 58.48%. This research aimed to find interferon (IFN) g level among households contact with tuberculosis patient that used a new screening method of finding tuberculosis cases. The research design was a two-year cohort study (2011 - 2013) took place in pulmonary community health centers Semarang. In the end of research, found 12 participants household contact and 13 participants nonhousehold contact. Wilcoxon test result showed significant differences IFN-g level between contact group and noncontact group (p value= 0.004). IFN-g among household contact group decreased in most cases (75%). Among household contact group showed 25% had a clinical symptom of tuberculosis. Microbiology diagnostic showed 100% had negative result in both group. Result of receiver operating characteristic IFN-g level toward clinical status, had value area under curve 70.4% (95% CI= 40.8%-99.9%). Cut off point of IFN-g value have optimal result in ³3.277, with sensitivity and specificity value 67.7%. IFN-g level test can be used in screening program to early detection of infected among household contact with new tuberculosis cases, as a pilot project in high prevalence of new tuberculosis cases.
Authors and Affiliations
Sri Andarini Indreswari, Suharyo Suharyo
Keywords
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- EP ID EP330985
- DOI 10.21109/kesmas.v9i1.453
- Views 63
- Downloads 0
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