Diagnosis of Dementia-Circadian Dependency?
Journal Title: Journal of Geriatric Medicine and Gerontology - Year 2017, Vol 3, Issue 1
Abstract
Little is known whether tests used for the diagnosis of dementia syndromes are sensitive to time of day effects. In a sample of 145 participants, no such effect (test administration either in the morning from 9.30 to 11.30 a.m. or in the afternoon from 2.30 to 4.30 p.m.) could be found for most subtests of a neurocognitive test battery (CERAD-Plus) used for the detection of dementia syndromes. However, for subjects suffering from mild cognitive impairment, completion time for the Trail-Making Test B, a brief cognitive test for the assessment of cognitive flexibility, was longer in the afternoon compared to the morning.
Toward Developing a Novel Neurocognitive Frailty Index in the Elderly
Background Frailty is an important geriatric syndrome and many efforts were made to measure and describe its properties, such as the Frailty Index (FI), clinical frailty and phenotype frailty. However, the majority of th...
Help-Seeking in Older Adults with Subjective Memory Complaints
Background: Evidence shows that subjective memory complaints (SMCs) could represent an important therapeutic period for people at risk for sustaining future cognitive decline, but current knowledge on the behaviour profi...
Phase II Clinical Trial of Nicotinamide for the Treatment of Mild to Moderate Alzheimer's Disease
Background: Disease-modifying treatments for Alzheimer's disease (AD) are currently unavailable and are the focus of an intensive research effort. We found vitamin B3, nicotinamide (NA), to significantly reduce pathology...
Analysis of the Treatment of Diffuse Large B-Cell Lymphoma in Patients with Preexisting Systolic and/or Diastolic Dysfunction at Moffitt Cancer Center
Introduction The treatment of choice for newly diagnosed patients with advanced Diffuse Large B Cell Lymphoma (DLBCL) is R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone). However older patien...
Loss of Organic Reserve as a Detector of Frailty in Elderly Cancer Patients Treated with Chemotherapy
This study aims to identify the presence of frailty in elderly cancer patients by analysing their functional reserve. In order to do so, a prospective study of oncological patients over the age of 70 years, assessed on a...