Diagnostic Accuracy of Intraoperative Frozen Section and Causes of Error in Ovarian Epithelial Tumors: An Institutional Experience
Journal Title: Middle East Journal of Cancer - Year 2017, Vol 8, Issue 3
Abstract
Background: Ovarian cancer is the second most common type of female genital tract malignancy. Treatment planning differs for benign, borderline, and malignant subtypes of surface epithelial tumors and depends on accurate histopathological diagnosis. The aim of this study is to determine the accuracy and causes for error in intraoperative diagnosis of ovarian surface epithelial tumors. Methods: In this retrospective study, we analyzed all cases of ovarian surface epithelial tumors referred to the Pathology Department of our hospital from April 2010 to December 2015. We considered the final diagnosis as the gold standard and determined the accuracy, sensitivity, specificity, positive predictive value, negative predictive value, underdiagnosis and overdiagnosis for each group of benign, borderline, and malignant tumors. An expert pathologist blinded to the diagnosis reviewed patients’ frozen and permanent slides and categorized causes of error into misinterpretation, sampling, and technical errors. Results: We assessed 220 patients’ slides (96 benign, 66 borderline, and 58 malignant tumors). The accuracy of the frozen section was: 98% in benign, 80.3% in borderline and 67.2% in malignant tumors. The frozen sections had a sensitivity of 97.9% for benign tumors and a sensitivity of 67.2% and specificity of 100% for malignant tumors. Borderline tumors had a sensitivity of 91% and specificity of 88.4%. Mucinous borderline tumors comprised the more frequent uncertain and underdiagnosed cases. The main cause for error in this group was sampling error. In malignant neoplasms, 15.5% were reported to be at least borderline. Technical issues were the cause of difficulty in interpretation. In the benign category, cystadenofibroma could be misinterpreted as a borderline malignancy. Conclusion: Frozen section is an accurate, specific method for diagnosis of benign and malignant tumors. In the borderline category, the results should be interpreted with caution.
Authors and Affiliations
Fatemeh Nili, Vahid Soleimani, Behnaz Jahanbin, Seyed Siamak Jalal-Alhoseini, Alireza Ghanadan
Keywords
Related Articles
- EP ID EP299668
- DOI -
- Views 93
- Downloads 0
A Child with Left Femoral Pain and Limping
Na
HER2 Overexpression in Borderline and Malignant Ovarian Tumors: A Cross-sectional Study in an Iranian Population and Literature Review
Background: Different studies have investigated the overexpression of human epidermal growth factor receptor 2 in ovarian cancers, in addition to the association between the level of its overexpression and tumor characte...
Association of Epstein-Barr virus with Esophageal Squamous Cell Carcinoma
Introduction: Esophageal squamous cell carcinoma is among the leading causes of cancer related deaths within gastrointestinal tumors. There is a growing body of evidence that shows an association between Epstein Barr vir...
Adherence to a Standardized Order Form for Gastric Cancer in a Referral Chemotherapy Teaching Hospital, Mashhad, Iran
Background: Standardized forms for prescription and medication administration are one solution to reduce medication errors in the chemotherapy process. Gastric cancer is the most common cancer in Iran. In this study, we...
IL-35 Serum Levels in Bladder Cancer Patients: An Analytical Cross-sectional Study
Background: Bladder cancer is a prevalent disease with significant health care costs and high rates of recurrence. Results from numerous studies to associate bladder cancer with serum biomarkers have been analyzed for pr...