Diagnostic difficulties in c-kit negative gastrointestinal stromal tumors: report of 4 cases
Journal Title: Revista de Medicină Militară - Year 2017, Vol 0, Issue 3
Abstract
Introduction: The gastrointestinal stromal tumors (GIST) are dominated by KIT and PDGFRA mutation. The immunohistochemical detection of CD117, a protein express by KIT gene, is essential for the diagnosis and those that are negative always represented a diagnostic challenge Case reports: In this article we present a series of 4 cases of CD117 negative GIST tumors, diagnosed and surgically resected in Fundeni Clinical Institute and an overview of the histogenesis, diagnostic problems and management of c-kit negative GIST. All patients were males and the tumors were located in the stomach and small bowel. Conclusion: It is important for the pathologists to beware of the fact that a CD117 negative in the context of a typical morphological appearance does not exclude a GIST tumor and also the oncologist must be aware not to exclude the therapy with imatinib based on the negativity of CD117.
Authors and Affiliations
Andreea Iorgescu, Vlad Herlea, Elena Stoica Mustafa, Catalin Pechianu, Alexandru Procop, Maria Sajin, Irinel Popescu
Keywords
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