DIAGNOSTIC DILEMMA IN A CASE OF GINGIVAL LESION PLASMA CELL GRANULOMA VERSUS EXTRAMEDULLARY PLASMACYTOMA- RESOLVED BY IMMUNOHISTOCHEMISTRY: A CASE STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 2
Abstract
Plasma cell granuloma is a rare reactive tumor- like lesion composed of polyclonal plasma cells. It primarily affects the lungs but occurs in other anatomic locations such as orbit, paranasal sinuses, larynx, tonsils, ears, tongue, lip, oral cavity and gingiva. A 65- year old female presented with the chief complaint of swelling over the right upper gingiva and mobility of right upper 2nd and 3rd molar teeth since 3-4 months At histopathology due to presence of uniform population of plasma cells a histopathological diagnosis of plasma cell rich lesion was made with a differential diagnosis of extramedullary plasmacytoma and plasma cell granuloma. However, immunohistochemical staining for kappa and lambda chains showed a polyclonal process and antibodies to CD138 were strongly positive, confirming the diagnosis of plasma cell granuloma. The case describes a rare condition of plasma cell granuloma occurring at an unusual site. Authors also emphasize the importance of immunohistochemistry in differential diagnosis of plasma cell rich lesions.
Authors and Affiliations
Amita K| Associate Professor, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Nagamangala taluk, Mandya, Karnataka, Corresponding author: Amita K Email: dramitay@gmail.com, Vijayshankar S| Professor, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Nagamangala taluk, Mandya, Karnataka, Anusha K| Post graduate, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Nagamangala taluk, Mandya, Karnataka, Hemalatha AL| Associate Professor, Department of Pathology, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Nagamangala taluk, Mandya, Karnataka
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- EP ID EP11423
- DOI 10.5958/2319-5886.2015.00089.2
- Views 298
- Downloads 13
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