Diagnostic importance of phenotypic featuresof undifferentiated connective tissue dysplasiain spondylogenic vertebro-basilar insufficiency
Journal Title: BOHR International Journal of Neurology and Neuroscience - Year 2024, Vol 2, Issue 1
Abstract
Background:The circulatory insufficiency in the vertebrobasilar system is significantly influenced by thespondylogenic mechanism. To understand the degenerative-dystrophic changes in the cervical spine, anassessment of the connective tissue’s condition is required. The primary contributor to pathological conditionsof connective tissue is undifferentiated connective tissue dysplasia (UCTD).Aim:To assess the predictive importance of constitutional-biological markers (CBM) of UCTD in patients withspondylogenic vertebro-basilar insufficiency.Materials and Methods:The research was carried out using the results of a comprehensive clinical andanamnestic examination of young patients with vertebrobasilar insufficiency. The study focused on investigatingthe main characteristics of CBM by comparing two groups of patients: one group with vertebrobasilar insufficiency(n = 136) and a control group without vertebrobasilar insufficiency (n = 136). The distribution of individual factorswas analyzed using evidence-based medicine, modern clinical-statistical analysis methods such as variance andcorrelation analysis, as well as prognosis methods like serial analysis of Wald in modification of E.V Gubler todetermine the diagnostic (I2, bit) and predictive value and impact factors of the different markers.Results:The most significant CBM for UCTD were found to be presence of structural imbalance, scoliosis orkyphosis of the cervical spine, flatfoot, and vision impairments.Conclusion:This study suggests that the diagnostic and prognostic value of CBM for UCTD is crucial inestablishing a system of diagnostic and prognostic algorithms for evaluating the risk of developing vertebrobasilarinsufficiency (SVBI).
Authors and Affiliations
Nekrasova Nataliya, O. Tovazhnyanska Rhea Singh
Keywords
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- EP ID EP742285
- DOI 10.54646/bijnn.2024.16
- Views 48
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