DIAGNOSTIC METHODS FOR NON-ALCOHOLIC FATTY LIVER DISEASES ALTERNATIVE TO LIVER BIOPSY: A REVIEW
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
Non-alcoholic fatty liver diseases (NAFLD) are the most occurring chronic liver diseases caused by hepatic manifestation of metabolic syndromeslike insulin resistance in Type-2 diabetes, obesity and hyperlipidemic condition. Indian men have a high prevalence of NAFLD. Genetic factor is alsoan important consideration for NAFLD. The core aim of this study is to focus on non-invasive biochemical markers for diagnosis of NAFLD as analternative to liver biopsy. Biopsy is the gold standard for NAFLD; however a variety of studies powerfully suggest that due to the limitation and riskof biopsy, as well as improvement of the diagnostic accuracy of biochemical markers, biopsy should no longer be considered obligatory. Thus, due tothe limitation of liver biopsy, numerous biomarkers has been developed recently, which may provide more accurate results than an inferior qualityliver biopsy. Some important biomarkers are caspase-cleaved cytokeratin-18, breath biomarker, circulating microRNAs, abdominal ultrasound,adipocytokines, etc.Keywords: Adipocytokines, Cytokeratin-18, Liver biopsy, MicroRNAs, Non-alcoholic fatty liver diseases, Non-invasive biomarkersÂÂ
Authors and Affiliations
Surendra H. Bodakhe, Sanjay Kumar Gupta
Keywords
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