Diagnostic utility of cartridge based nucleic acid amplification test (CBNAAT) in detection of rifampicin resistance in multi drug resistant suspects among sputum positive cases of tuberculosis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 1
Abstract
Tuberculosis has claimed its victims throughout much of known human history. CBNAAT (Xpert MTB/ RIF) is a fully automated diagnostic test which simultaneously detects tuberculosis and rifampicin drug resistance within few hours. The present study was conducted to show the diagnostic ability of CBNAAT in detecting rifampicin resistance with consideration of the diabetic status. The present study was carried out in the department of Chest and Tuberculosis, Government medical college, Amritsar and included 100 patients diagnosed with tuberculosis as MDR suspects. Most of the patients under study were below 60 years, mostly lying in the age grp <=40years (55%). The study showed that males predominated the study being 72% of the total patients with male: female ratio of 2.6:1. 33% of patients belonged to group II i.e. CAT 2 regimen failure. 27% of the subjects were diabetics (16% male and 11% female). It was found that 52% of the patients fell in weight band – B i.e. weighing between 26 to 45kg while diabetic subjects belonged to weight band of 46-70kg (11%). There was almost equal distribution of subjects in urban (47%) and rural setting (53%). Distribution of diabetics was also almost equal in rural (14%) and urban population (13%). Family history of ATT was present in 17% of the subjects and was found out to be statistically significant (p <.006). Also, family history of ATT was seen in 3% of the diabetics and 14% of the non-diabetics and was found out to be statistically significant (p< .029). Total 26% of the subjects had smoking addiction out of which 5% had diabetes, 59% were alcoholics out of which 15% were diabetic, 6% had tobacco addiction out of which 2% had diabetes and 2% were capsule addicts with non-diabetic status. Thus, majority of subjects in the study are re-treatment cases who are sputum positive at 4 months or later. Keywords: Tuberculosis, CBNAAT, Diabetes, Rifampicin drug resistance
Authors and Affiliations
Naveen Pandhi, Nirmal Chand Kajal, Nidhi Mahajan, Hardip Singh
Keywords
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