Diagnostic utility of Ki-67 as a proliferative marker & the expression of Galectin-3 in Neoplastic and Non-neoplastic lesions of thyroid.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 12
Abstract
Thyroid neoplasms constitute the most commonly occurring endocrine tumors worldwide. Owing to the wide spectrum of clinical behaviour & varied therapeutic responsiveness, early diagnosis of thyroid tumors and appropriate management will prolong the survival rate of patients. However, distinguishing various thyroid lesions by hematoxylin and eosin sections alone is really challenging to a pathologist. The use of ancillary techniques like IHC is imperative for a definite diagnosis. The present study has used Galectin-3 for differentiating the neoplastic thyroid lesions from the non-neoplastic ones. Neoplastic thyroid lesions showed predominantly a strongly positive diffuse staining intensity with Galectin while non neoplastic thyroid lesions exhibited predominantly weak staining. Overall, the sensitivity and specificity of galectin -3 in distinguishing both neoplastic and non neoplastic thyroid lesions came to be 91.6% and 58.3% respectively. Positive predictive value and Negative predictive value was 68.7% and 77.7% respectively. Ki-67 labeling was found to be significantly higher in Neoplastic thyroid carcinomas than in non neoplastic tumors. Senstivity, specificity, positive predictive value and negative predictive value as 80.76%, 76.16%, 67.7%, and 70.16% respectively. Conclusion: Gal-3 proves to be good candidate marker of malignancy especially in differential expression in neoplastic thyroid carcinomas when compared with non neoplastic thyroid lesions. Ki-67 immunohistochemical staining though can differentiate between neoplastic and non neoplastic thyroid lesions, it is not significantly helpful in differentiating between benign and malignant thyroid lesions.
Authors and Affiliations
Dr. Anamika Sharma, Dr. Jaspreet Singh, Dr. K. S. Chahal, Dr. Surinder Paul, Dr. N. S. Neki
Keywords
Related Articles
- EP ID EP548954
- DOI 10.22192/ijcrms.2018.04.12.003
- Views 223
- Downloads 0
Effect of alterations in breathing patterns on EEG activity in normal human subjects
Hypoxemia, hyper/hypocapnia due to altered respiratory patterns in patients with chronic respiratory ailments cause changes in cortical functions leading to encepalopathy. But presence of other simultaneous confounding f...
Antimicrobial and anthelmintic activity of new herbal siddha formulation
Herbs have an inevitable role in human life. Remedies prepared from herbs are being used variedly for several centuries. Objective of the present study was to investigate the antimicrobial and anthelmintic activity of th...
Effect of Siddha medicine and Varma therapy for the management of Erb’s Palsy – A Case study
A 9 month old female baby, with complaints of complete paralysis of right upper limb with typical waiter’s tip deformity, diagnosed as Erb’s palsy was brought to National Institute of Siddha, Kuthandhai Maruthuvam OPD ....
Clinicopathologial evaluation of lymphadenopathy by FNAC in children and adolescents
Introduction: Lymph nodes are commonly involved in both children and adolescents in local and systemic conditions such as infections, lymphomas and metastatic deposits. FNAC is simple procedure used to diagnose such lesi...
Thyroid profile in multi transfused children of beta Thalassemia major and its correlation with serum ferritin levels
Background: Thalassemia major is a hereditary anemia which is caused by defective synthesis of hemoglobin, ineffective erythropoiesis and rapid erythrocyte breakdown. Transfusions in beta thalassemia major are necessary...