Diagnostic utility of Ki-67 as a proliferative marker & the expression of Galectin-3 in Neoplastic and Non-neoplastic lesions of thyroid.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 12
Abstract
Thyroid neoplasms constitute the most commonly occurring endocrine tumors worldwide. Owing to the wide spectrum of clinical behaviour & varied therapeutic responsiveness, early diagnosis of thyroid tumors and appropriate management will prolong the survival rate of patients. However, distinguishing various thyroid lesions by hematoxylin and eosin sections alone is really challenging to a pathologist. The use of ancillary techniques like IHC is imperative for a definite diagnosis. The present study has used Galectin-3 for differentiating the neoplastic thyroid lesions from the non-neoplastic ones. Neoplastic thyroid lesions showed predominantly a strongly positive diffuse staining intensity with Galectin while non neoplastic thyroid lesions exhibited predominantly weak staining. Overall, the sensitivity and specificity of galectin -3 in distinguishing both neoplastic and non neoplastic thyroid lesions came to be 91.6% and 58.3% respectively. Positive predictive value and Negative predictive value was 68.7% and 77.7% respectively. Ki-67 labeling was found to be significantly higher in Neoplastic thyroid carcinomas than in non neoplastic tumors. Senstivity, specificity, positive predictive value and negative predictive value as 80.76%, 76.16%, 67.7%, and 70.16% respectively. Conclusion: Gal-3 proves to be good candidate marker of malignancy especially in differential expression in neoplastic thyroid carcinomas when compared with non neoplastic thyroid lesions. Ki-67 immunohistochemical staining though can differentiate between neoplastic and non neoplastic thyroid lesions, it is not significantly helpful in differentiating between benign and malignant thyroid lesions.
Authors and Affiliations
Dr. Anamika Sharma, Dr. Jaspreet Singh, Dr. K. S. Chahal, Dr. Surinder Paul, Dr. N. S. Neki
Keywords
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- EP ID EP548954
- DOI 10.22192/ijcrms.2018.04.12.003
- Views 262
- Downloads 0
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