Diagnostic Value of the Mean Platelet Volume in the Prediction of Respiratory Syncytial Virus in Acute Bronchiolitis
Journal Title: The Journal of Pediatric Research - Year 2019, Vol 6, Issue 1
Abstract
Aim: Respiratory syncytial virus (RSV) is a viral pathogen that causes lower respiratory system infections in childhood. The purpose of this study was to examine whether mean platelet volume (MPV) changes are significant in the prediction of RSV bronchiolitis. Materials and Methods: One hundred and eighty-four infants who were diagnosed with acute bronchiolitis were divided into groups based on being RSV positive and other respiratory viruses positive. Using the receiver operating characteristic (ROC), diagnostic accuracy was evaluated according to the areas under the curves (AUC) for the diagnosis of bronchiolitis. A p value of <0.05 was considered statistically significant. Results: MPV was significantly lower in patients with single RSV (6.6±1.1 vs 7±1.2, p<0.05). The MPVs were similar in patients diagnosed with positive and negative RSV bronchiolitis (6.8±1.5 vs 7±1.3, p>0.05) and other viruses. ROC curve analysis indicates that the MPV level cut-off point for making the diagnosis of single RSV bronchiolitis was 6.63 fL with a sensitivity and specificity of 55% and 63% respectively. The median AUC was 0.384 for the MPV (95% CI 0.270-0.499, p=0.04). Conclusion: Volume of MP may be a useful marker to provide a prediction on single RSV bronchiolitis. However, the measurement of MPV might not be correct and sufficient to provide a prediction on the types of respiratory viruses in bronchiolitis.
Authors and Affiliations
Şule Gökçe, Zafer Kurugöl, Güldane Koturoğlu, Aslı Aslan, Sibel Polater, Candan Çiçek
Keywords
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- EP ID EP549490
- DOI 10.4274/jpr.galenos.2018.53325
- Views 89
- Downloads 0
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