Diagnostic Yield of Post-mortem Needle Biopsies and their Spectrum: Experience from a Tertiary Care Hospital
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 7
Abstract
ABSTRACT Introduction: Conventional autopsy provides important information regarding cause of death, clinico-pathological correlation and is a paramount source of learning. Developing countries have low acceptance rates, denial and limited accessibility for conventional autopsy. Needle autopsy has come up as an alternative to conventional autopsy. Aim: Aim of the study was to analyse postmortem needle biopsies to gauge their utility in lending postmortem diagnosis as well as study its spectrum. Materials and Methods: This was a retrospective study and includes 334 patients. Different organs sampled were liver, lung, kidney, spleen, brain, heart, testis, lip and nose. Clinical data and histopathology slides were retrieved and reviewed by three pathologists. Results: A total of 428 biopsies were received from 334 patients. Forty five (10.5%) biopsies from different organs were non representative. A definite diagnosis was offered in 304 biopsies with an overall diagnostic yield of 79.4%. Liver and kidney biopsies had the maximum diagnostic yield of 89.2% and 69.2%, respectively and most diagnostic category encountered were multiacinar necrosis and fungal infection respectively. Major disagreement (Class 1 and Class 2) between clinical diagnosis and needle autopsy diagnosis was found to be in 21/334 cases (6.3%), where patient would potentially have survived if the clinical diagnosis had been correct. Conclusion: Diagnostic dilemma is a wistful part of medical science. Postmortem needle biopsy has an important role in diagnosis making, improvising the quality of academics and patient care. Level of information and diagnostic yields are high with liver and kidney.
Authors and Affiliations
Neha Nigam, Niraj Kumari, Narendra Krishnani, Ranjana Ranade
Keywords
Related Articles
- EP ID EP606904
- DOI 10.7860/JCDR/2019/37907.13005
- Views 110
- Downloads 0
Role of Sonourethrogram in Evaluation of Anterior Urethral Stricture and its Correlation with Retrograde Urethrogram and Intraoperative Findings-A Prospective Study
ABSTRACT Introduction: Urethral strictures are common in young adult males causing significant morbidity and discomfort. Retrograde Urethrography (RGU) and Sonourethrography (SUG) have been widely used to diagnose and ch...
Should the Urologist Demarcate the Surgical Specimen after Radical Prostatectomy
ABSTRACT Introduction: Although the literature about prostate cancer is vast in tracking discussion about diagnosis and treatment of prostate cancer, there are few publications about the best form of surgical specimen pr...
Healthcare Associated Infection in Paediatric Intensive Care Unit-A Tertiary Care Hospital Experience
ABSTRACT Introduction: Healthcare Associated Infections (HAI) are those that are acquired in a health care setting or one that is acquired in the hospital environment by a patient who had been admitted to the hospital f...
Factors that Predict the Response to Treatment in Carpal Tunnel Syndrome
ABSTRACT Introduction: Carpal tunnel release is a very common surgery and most people do very well after the surgery but some pre-existing conditions can have a negative impact on the outcome of the surgery. Our current...
Surgical Removal of Fractured Endodontic Instrument Extending Beyond the Periapex of Mesiobuccal Root of Maxillary Second Molar through the Maxillary Sinus
Procedural accidents during endodontic treatment often complicate the overall treatment plan of the patient. One of the most frequently encountered procedural accidents is fracture of endodontic instrument. Removal of fr...