Diclofenac Sodium Loaded Nanosized Ethosomes: An Investigation on Z-Average, Polydispersity and Stability
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID). Oral therapy with NSAID is always associated with several side effects such as gastric bleeding, and ulceration. The purpose of this work was to explore the feasibility of power ultrasound in designing a noval ethosomal carrier based on Phosphatidyl choline (PC) and ethanol for topical application of Diclofenac sodium, and further to investigate Z-Average (nm), polydispersity index (PDI) and zeta potential (mV). The designed drug loaded ethosomes had Z-Average of 440.3nm, PDI of 0.56, and zeta potential of -35.2 mV. The obtained results demonstrated feasibility of power ultrasound in achieving nanosized drug loaded ethosomes though PDI value (above 0.5) was clearly indicative of broad distribution of particles. The zeta potential value of -35.2 mV substantiated stability of Diclofenac sodium loaded ethosomes
Authors and Affiliations
Manwar JV, Patil SS, Patil B, Jadhao RG, Kumbhar DD* and Bakal R
Diclofenac Sodium Loaded Nanosized Ethosomes: An Investigation on Z-Average, Polydispersity and Stability
Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID). Oral therapy with NSAID is always associated with several side effects such as gastric bleeding, and ulceration. The purpose of this work was to explor...
β-Carbonic Anhydrase as a Target for Eradication of Mycobacterium tuberculosis
Infectious diseases are among the most danger, and deadly afflictions that human societies suffering from there. One of the common re-emerged infectious diseases is tuberculosis (TB). The causative pathogen for this dise...
Chikungunya Emerging Health Crises in Pakistan: Are we Going in the Right Direction
The unstable health care system of Pakistan saw a major setback in the form of dengue outbreak in 2011. Despite massive governmental efforts, with each passing year dengue continues to cause significant morbidity and mo...
Medication Errors
These results relied on data voluntary provided to American Hospital Association. It is likely that substantial number of medication errors go undetected or unreported to the hospital medication error reporting system.
Transferosomes for Trans-Nasal Brain Delivery of Clonazepam Preparation Optimization Ex Vivo Cytotoxicity and Pharmacodynamic Study
Clonazepam (CZ) is a benzodiazepine derivative that is used mainly in the treatment of status epilepticus (SE). Intranasal (IN) administration of nano-carrier systems generally have the ability to deliver the drug to the...