Diet and estradiol level in adolescent girls
Journal Title: Paediatrica Indonesiana - Year 2016, Vol 56, Issue 3
Abstract
AbstractBackground Nutritional intake in adolescent girls in Indonesia has been well studied, but there has been little study on its influence on serum estradiol levels. A high estradiol level has been associated with higher risk of breast carcinogenesis.Objective To evaluate the influence of dietary factors on serum estradiol concentration in adolescent girls.Methods A community-based survey was conducted in female junior high school students in Jakarta from January 2014 to January 2015. Nutritional intake was assessed by semi-quantitative food frequency questionnaires (FFQ), which included the intake of total energy (kcal), carbohydrate (g), protein (g), fat (g), fiber (g), and phytoestrogen (g). Based on the Indonesian recommended daily allowance (RDA), energy and nutrient intakes were categorized as minimal (<70%), low (70-99.9%), normal (100-129.9%), and high (≥130%). Serum estradiol levels were measured during the follicular phase using an enzyme-linked immunosorbent assay (ELISA).Results A total of 189 girls aged 13-15 years were enrolled from 8 junior high schools across the municipalities of Jakarta. Twenty-eight (14.8%) subjects were overweight or obese. Median estradiol level was 41.83 (range 13.14-136.5) pg/mL. Serum estradiol level was significantly correlated with energy, protein, and fat intake. Estradiol level was also significantly associated with carbohydrate (P=0.030) and fat (P=0.036) intake status. Multivariate analysis revealed that intake of energy, protein, and fat, as well as body mass index (BMI) were independent predictors of estradiol levels. However, due to its importance as energy source, we included carbohydrate intake in the final equation to predict estradiol level as follows: E2 = 60.723 – 0.053 (energy) + 0.185 (carbohydrate) + 0.483 (protein) + 0.491 (fat) – 1.081 (BMI).Conclusion Serum estradiol levels in adolescent girls aged 13-15 years are influenced by diet, especially fat intake. Estradiol levels can be predicted from energy, carbohydrate, protein, and fat intake, as well as BMI. [Paediatr Indones. 2016;56:134-8.].
Authors and Affiliations
Ririn Hariani, Saptawati Bardosono, Ratna Djuwita, Noorwati Sutandyo, Melani Kumala, Ali Sungkar, Rini Sekartini
Keywords
Related Articles
- EP ID EP446132
- DOI 10.14238/pi56.3.2016.134-8
- Views 54
- Downloads 0
Effects of Nigella sativa oil on Th1/Th2, cytokine balance, and improvement of asthma control in children
Background Asthma is a chronic inflammatory disease of the airways characterized by involvement of a variety of inflammatory cells. Asthma is associated with imbalances between Th1/Th2 cells and their characteristic cyto...
Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children
Background Heart failure affects morbidity and mortality in children with heart disease. There is no single, specific test to diagnose heart failure. The modified Ross Reithmann scoring system has been used to classify...
Association between passive smoking and Mycobacterium tuberculosis infection in children with household TB contact
Background Tuberculosis (TB) and cigarette consumption are relatively high in Indonesia. Passive smoking may increase the risk of infection and disease in adults and children exposed to TB. An association between passive...
Risk factors of soil-transmitted helminth infection among elementary school students
Background Helminth infection remains a health problem, especially in school-aged children. Mass eradication programs with a single dose of anti-helminthic drugs were employed by the local government in some endemic area...
Effect of community-based food supplementation on improving growth of underweight children under five years of age in West Nusa Tenggara
Background The prevalence of underweight children in West Nusa Tenggara is as high as 30%. This region had the third largest number of stunted children in the country. The local government has attempted to tackle this pr...