Dietary and Serum Level of Antioxidants in the Elderly with Mild Impaired and Normal Cognitive Function: A Case-Control Study
Journal Title: UNKNOWN - Year 2018, Vol 20, Issue 11
Abstract
Background: Antioxidants are considered essential components in neurodegenerative disease management since they can protect cells from oxidative damage. Objectives: The current study aimed at evaluating the intake and serum level of selected antioxidants in subjects possessing mild cognitive impairment (MCI) compared with a cognitively intact control. Methods: The current prospective, case-control study was conducted in Tabriz from December 2016 to August 2017 on a total of 45 patients with MCI as a case group and another 45 healthy subjects matched by age and gender were recruited for the control group. After completing the mini-mental state examination (MMSE-12) questionnaire, the cases with MCI were identified using the modified Peterson standard. By a semi-quantitative food frequency questionnaire (FFQ), the common dietary intakes during the previous year were recorded and blood samples were collected. Results: Of the 90 subjects in the current study, 61% were male and 39% female, with the mean age of 68.8 ± 5.5 years. There were no significant differences between the two groups with respect to dietary intakes of vitamin C, beta-carotene, and lycopene (P = 0.079, P = 0.413, and P = 0.455, respectively). The results of the studied parameters showed that serum beta-carotene and lycopene (P = 0.004 and P = 0.044, respectively) in healthy subjects were significantly higher than those of the elderly people with MCI. There was a significant correlation between Vitamin C dietary intake and serum level and cognitive scores in MMSE-12 (r = 0.231, P = 0.028 and r = 0.224, P = 0.033, respectively) and also between serum level of lycopene and cognitive scores(r = 0.388, P = 0.000). Conclusions: The subjects with mild cognitive impairment had a significantly lower serum levels of lycopene beta-carotene antioxidants compared with healthy subjects, and there was a positive correlation between serum level of vitamin C and lycopene and also vitamin C dietary intake and scores in the MMSE-12 test.
Authors and Affiliations
Hormoz Ayromlou, Parisa Pourvahed, Fatemeh Jahanjoo, Homayoun Dolatkhah, Seyyed Kazem Shakouri, Neda Dolatkhah
Keywords
Related Articles
- EP ID EP427699
- DOI 10.5812/ircmj.64847
- Views 71
- Downloads 0
Health-Related Quality of Life and Socioeconomic Status: Inequalities among Adults in West of Iran
Background: Socioeconomic status (SES) is one of the main determinants of health-related quality of life (HRQoL), where people with lower SES experience more health problems, have a lower quality of life, and are exposed...
Retropectoral Cystic Echinococcosis: A Case Report
Background: Cystic echinococcosis of soft tissue is rare even in endemic areas. Intermuscular and intramuscular cystic echinococcoses have been occasionally reported in the literature. Case Presentation: A 40-year-old ma...
Concept Analysis of Clinical Judgment in Nursing Students: A Hybrid Model
Background: Clinical judgment (CJ) is a complex process and is one of the most important concepts in the domain of education of the nursing students. Despite the special importance of its concept in nursing, this term st...
Comparing the Effect of Electronic Software and Training Booklet on Maternal Self-Confidence and Awareness About Newborn Care: A Randomized Controlled Clinical Trial
Background: The use of a training booklet and electronic software has a special place due to lack of time and space constraints. Objectives: This study aimed to compare the effect of electronic software and training book...
3D Detected a Missed IUD Despite Threads at the Cervix in Post Caesarean Section Delivery: A Case Report
Introduction: Intrauterine devices (IUDs) have been used as a commonly convenient, efficient, relatively safe, and inexpensive method of contraception worldwide. Contraceptive efficacy is related to intrauterine location...