Dietary Changes with Omega-3 Fatty Acids Improves the Blood Lipid Profle of Wistar Albino Rats with Hypercholesterolaemia
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 3
Abstract
Background: Lipid profle is a reasonably reliable parameter for the assessment of cardiovascular risk, besides the anthropometric measurements. Serum lipid dysfunctions in the HDL and LDL components are commonly observed in cardiac patients. Omega-3 fatty acids exhibit a hypolipidemic potential which could be exploited in preventing the onset of this alarmingly increasing problem globally. Aims: To evaluate and compare the effects of different sources of omega-3 fatty acids, on the lipid profle parameters in rats induced with hyperlipidaemia. Methods and material: In our present study, we supplemented omega-3 oils from the plant source as well as the fsh source to hypocholesteraemia induced Wistar albino rats for a period of three months. Wistar albino rats were fed normal chow along with 1% cholesterol for a period of three months to induce hypocholesteraemia. To this 1% flax oil and 0.1% fsh oil were mixed separately and fed to two groups of rats for another period of three months to check for hypolipidemic effects if any. Results and conclusions: A signifcant reduction in total cholesterol, LDL, and glucose levels with increases in HDL levels in the flax oil as well as fsh oil groups is observed. Also, a noticeable change though not signifcant was observed in the plasma triglyceride concentrations afer the supplementation period. Tis signifcant hypolipemic effect by omega-3 fatty acids from both the sources, demonstrates their possible therapeutic use in patients with cardiac risk.
Authors and Affiliations
Shahida A Khan| Applied Nutrition Group, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabiaو Corresponding e-mail: sakhan01@kau.edu.sa, shahidakhan2009@gmail.com, Ahmad Makki| Applied Nutrition Group, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
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