DIFFERENCE SPECTROPHOTOMETRIC ESTIMATION OF PRASUGREL HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
A simple, precise and accurate difference spectroscopic method has been developed for the estimation of prasugrel hydrochloride in bulk and in pharmaceutical dosage form. The proposed method is based on the principle that prasugrel hydrochloride exhibits in two different chemical forms that differs in the absorption spectra in basic and acidic medium. The absorbances were measured in acidic and basic solution separately against reagent blank. Prasugrel hydrochloride has exhibited maximum absorbance at 254 nm and 239 nm in acidic and basic solution respectively. Difference in absorbances between these two maxima was calculated to find out the amplitude. The amplitude plotted against concentration, showed linear response in the concentration range of 5-30 µg/ml with the linear regression value 0.997. The proposed method was applied to pharmaceutical formulations and the common excipients present in the formulation did not interfere in the analysis of the drug. The method was validated as per ICH guidelines and statistical results of analysis were found to be satisfactory.
Authors and Affiliations
Darshali Desai , Bharati Barmecha , Sanjay Walode
Keywords
Related Articles
- EP ID EP135224
- DOI -
- Views 94
- Downloads 0
MOIST WOUND HEALING: PERSPECTIVES FROM AYURVEDA
Wounds are a primary affliction. The healing of wounds is a complex mechanism that calls for a multipronged approach. Wounds have been observed to heal faster in a moist atmosphere as compared to a dry environment. Ayurv...
BIOACTIVE AND NUTRACEUTICAL COMPOUND MANIPULATION IN HIBISCUS SABDARIFFA L. LEAVES: A COMMON UNDERSHRUB CONSUMED BY THE BODO TRIBES OF BTC, ASSAM, INDIA
Hibiscus sabdariffa L. is a gregarious under shrub, which is traditionally consumed by the Bodo tribes of Assam, India as a major constituent of food. Ethno medicinally the leaves, flowers and fruits are used for stomach...
MICROPROPAGATION OF CROTON BONPLANDINUM BAIL.
Croton bonplandinum Bail. with its amazing colors and leathery leaves is regarded as a beautiful foliage plant. The plant is native of South America. Generally crotons are multiplied vegetatively by means of cuttings and...
COMPARATIVE STUDY OF IN-PROCESS AND FINISHED PRODUCTS QUALITY CONTROL TESTS OF INDIAN PHARMACOPOEIA, BRITISH PHARMACOPOEIA & UNITED STATES PHARMACOPOEIA FOR CAPSULES AND LIQUID ORALS
Present study deals with a brief overview of the comparative study of quality requirements for in-process and finished products quality control Tests of Indian Pharmacopeia (IP), British Pharmacopeia (BP) & United St...
MOUTH DISSOLVING FILM AND THEIR PATENT: AN OVERVIEW
Now days the researchers are focusing on the fast dissolving dosage form (FDDF’s).The fast dissolving dosage forms includes the mouth dissolving tablets, mouth dissolving thin films .The alternative words used for thes...