Different doses of oxycodone on postoperative pain-causing substance levels and tissue perfusion and intestinal barrier in patients undergoing gastrointestinal cancer surgery
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 8
Abstract
Objective To investigate the impact of different doses of oxycodone on postoperative levels of pain-causing substances, tissue perfusion, and intestinal barrier in patients undergoing gastrointestinal tumor surgery. Methods Forty-five patients with gastrointestinal tumors who underwent surgery at Lu'an Hospital of Traditional Chinese Medicine from June 2020 to January 2023 were selected and randomly divided into three groups, with 15 in each group. During the anesthesia process, group A received 0.08 mg/kg oxycodone, group B received 0.10 mg/kg oxycodone, and group C received 0.12 mg/kg oxycodone. The blood flow perfusion index (PI) was recorded at anesthesia induction (S1), endotracheal intubation (S2), 30 minutes after the start of surgery (S3), and at the end of surgery (S4). The levels of pain-causing substances ［5-hydroxytryptamine (5-HT) and substance P (SP)］ were detected 1 day before surgery and 2 days after surgery. The intestinal barrier function ［diamine oxidase (DAO), D-lactic acid, and endotoxin (ET)］ was assessed 1 day before surgery and 2 days and 4 days after surgery. Adverse reactions during anesthesia were recorded for the three groups. Results The PI levels of the three groups at S2, S3, and S4 were significantly higher than those at S1, and in group A was higher than in groups B and C (P＜0.05). On 2 days after surgery, the serum levels of 5-HT and SP in three groups were significantly higher than those before surgery, and in group A was higher than in groups B and C (P＜0.05). On 2 days and 4 days after surgery, the serum levels of DAO, D-lactic acid, and ET in three groups were significantly lower than those before surgery, and in group A was lower than in groups B and C (P＜0.05). The overall incidence of adverse reactions during anesthesia in groups A, B, and C (20.00%, 26.67%, 26.67%) showed no statistically significant difference (P＞0.05). Conclusion Compared to 0.08 mg/kg or 0.12 mg/kg oxycodone, anesthesia with 0.10 mg/kg oxycodone can effectively maintain the stability of postoperative pain-causing substances, PI, and intestinal barrier function in patients undergoing gastrointestinal tumor surgery, with good safety.
Authors and Affiliations
MA Qigang, XU Guanghong, GAO Gui, CHENG Zhikun （Department of Anesthesiology, Lu'an Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine, Lu'an, Anhui 237006, China）
Keywords
Related Articles
- EP ID EP743098
- DOI 10.13429/j.cnki.cjcr.2024.08.015
- Views 15
- Downloads 0
Preliminary construction of a prediction model for HBV-related acute-on-chronic liver failure combined with acute kidney injury
<b>Objective</b> To establish a model that can predict the occurrence of acute kidney injury (AKI) in elderly patients with HBV-related acute-on-chronic liver failure (HBV-ACLF), and to conduct a preliminary evaluation...
Research progress on posterior cervical foraminotomy for the treatment of cervical spondylotic radiculopathy
The incidence of cervical spondylotic radiculopathy is relatively high among cervical spine diseases. Surgical options for its treatment include anterior cervical discectomy and fusion, disc arthroplasty, and posterior c...
Efficacy of robot-assisted full-endoscopic transforaminal lumbar interbody fusion in the treatment of degree Ⅰand Ⅱ lumbar spondylolisthesis
<b>Objective</b> To evaluate the efficacy of robot-assisted full-endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) in the treatment of grade Ⅰ and Ⅱ lumbar spondylolisthesis. <b>Methods</b> The clinical dat...
Research progress of lung cancer complicated with pulmonary embolism
Pulmonary embolism and deep venous thrombosis are collectively referred to as venous thromboembolism, while pulmonary embolism is generally caused by deep venous thrombosis, which has the characteristics of sudden and mo...
Comparative study of three ways for treating the appendiceal stump after acute appendicitis under laparoscopy
Objective To investigate the advantages and disadvantages of purse-string suture, Hem-o-lok clip and double thread ligation in the treatment of appendiceal stump. Methods A retrospective study was conducted on 237 acute...