Differential Expression of Claudin-1, Claudin-3, and Claudin-4 in Bladder Lesions
Journal Title: Journal of Cancer and Tumor International - Year 2015, Vol 2, Issue 3
Abstract
Aims: Claudins are major transmembrane proteins of tight junctions. As the disruption of their function have important impact on tumorogenesis, invasion and metastasis. Claudins became a focus of interest for targeting therapies. Although their expression profiles have been studied in many organs, researches on Claudin expression in bladder are in limited number. The aim of this study is to present the differential expression of Claudin-1, Claudin-3 and Claudin-4 in invasive and noninvasive urothelial lesions. Study of Design: Several groups of noninvasive and invasive urothelial lesions were stained immunohistochemically by Claudin-1, Claudin-3 and Claudin-4 and their expressions were evaluated. Place and Duration of Study: Department of Pathology of Diskapi Research and Training Hospital, Ankara, between 2011-2013. Methodology: 83 cases (31 invasive urothelial carcinomas (IUCC) –further divided into: 15 muscle invasive UCCs, 16 UCCs with lamina propria invasion-, 17 noninvasive papillary urothelial carcinomas (NPUC), 13 papillary urothelial neoplasms of low malignant potential (PUNLMP), 7 carcinoma in situ (CIS) and 15 normal independent samples (CG). Sections from formalin-fixed paraffin embedded tissues were immunohistochemically stained with Claudin 1, Claudin 3 and Claudin 4. Results: Claudin-1 expression is significantly lower in low grade noninvasive urotelial carcinomas compared to invasive carcinomas. Claudin-3 is highly expressed in normal urothelium and invasive lesions; but its expression is decreased significantly in all non-invasive lesions. Claudin-4 expression appeared to decrease in muscle invasive UCC and CIS vs. others. Conclusion: Although higher expression of Claudin-4 in low-grade and non-invasive lesions may be used as a diagnostic tool, decreased expression of Claudin-4 can indicate more invasive capacity of the tumour. In terms of Claudin-1 and -3, their decreased expression in non-invasive lesions when compared to control group and their trend to show more increased expression in IUCC needs to be studied further in larger studies.
Authors and Affiliations
Tuba Dilay Kokenek-Unal, Ipek Coban, Ayse Selcen Oguz-Erdogan, Hatice Seneldir, Nesrin Gurcay, Murat Alper
Keywords
Related Articles
- EP ID EP242966
- DOI 10.9734/JCTI/2015/19336
- Views 98
- Downloads 0
The Implication of the Preoperative Neutrophil to Lymphocyte Ratio in the Diagnosis of Laryngeal Squamous Cell Carcinoma: A Retrospective Analysis
Aims: There is growing evidence that the neutrophil to lymphocyte ratio (NLR) may be used as a prognostic factor in many head and neck cancer types. We aimed to investigate the diagnostic implication of the NLR as a biol...
A Review on Primary Angiosarcoma of the Prostate Gland: An Update
Primary angiosarcoma of the prostate (PASOP) is a very rare tumour which most clinicians have not encountered and may be unaware of Literature of PASOP was reviewed by obtaining information from various internet data bas...
Intracranial Hemangiopericytoma in a 15 Year-old Child: Neuroimaging Features and Management Therapy
Introduction: Intracranial hemangiopericytoma (HPR) is a highly vascular tumors which is exceptional in children. They may present management difficulties in some cases. Clinical Presentation: The authors report the case...
Mucosal Melanoma of the Sino-nasal Tract - A Rare Case Report
Sino nasal malignant melanoma is a very aggressive and rare neoplasm of the head and neck region. Less than 2% of all mucosal melanomas originate from the sino-nasal region demanding a high index of suspicion to diagnose...
Role of Oncogenes and Tumor Suppressors in Metabolic Reprogramming and Cancer Therapeutics: A Review
Recently there has been a renewed interest on the signaling pathways and metabolic changes in cancer cells. It is well known that there are several oncogenes and tumor suppressors that affect cancer metabolism and re-eng...