DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE FORM AND IN PHARMACEUTICAL PREPARATIONS USING A STATIC MERCURY DROP ELECTRODE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: Objective of study was to develop a simple, precise and accurate differential pulse polarographic analysis (DPPA) of rosuvastatin (RSV) in pure form and in pharmaceutical preparations.Methods: The DPPA was applied in Na2HPO4 buffer at pH 1.5 using a static mercury drop electrode (SMDE).Results: One redaction peak was observed in the range -951 to -970 mV (Ep). The peak current Ip is linear over the ranges 9.631-1926.10 ng. mL-1. The relative standard deviation did not exceed 3.8% and regression analysis showed a good correlation coefficient (R2= 0.9999). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 1.22 and 3.70 ng. mL-1, respectively. The amount of RSV in different pharmaceutical preparations was decreases with the time (2-3% after one year) and the relative decrease was more in the tablets which contain lesser amount of RSV.Conclusion: The proposed method was successfully applied to the analysis of RSV in pure and pharmaceutical dosage forms with an average recovery of 92.50 to 101.35%.Â
Authors and Affiliations
Abdul Azizs Ramadan, Hasna Mandil, Nour Ghazal
Keywords
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