Differentially expressed miRNAs in premature infants with retinopathy-a bioinformatics analysis
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 5
Abstract
"AIM: To reveal the role of miRNAs in retinopathy of prematurity (ROP) by bioinformatics analysis. METHODS: The raw data of this study came from the researches of Wang et al and Zhao et al who analyzed the microRNA (miRNA) expression profile between ROP and controls. Based on the identified differentially expressed miRNAs, the related target genes, lncRNA and circRNA were predicted. Then we performed functional enrichment analysis to further analyze the functions of target genes. RESULTS: Hsa-miRNA-128-3p and hsa-miRNA-9-5p showed significantly different expression in both studies. LncRNA of POLDIP2, GAS5, NEFL and UHRF1, circRNA of ZNF280C_hsa_circ_001211 and SIAE_hsa_circ_002083, target gene of QKI showed meaningful differential expression in ROP. Enrichment analysis showed that TGF-β signaling pathway, PI3K-Akt signaling pathway and MAPK signaling pathway might play important roles in the progress of ROP. CONCLUSION: This research may provide a comprehensive bioinformatics analysis of differentially expressed miRNAs which are possibly involved in ROP."
Authors and Affiliations
Rui Cheng
Keywords
Related Articles
- EP ID EP489846
- DOI 10.18240/ijo.2018.05.09
- Views 62
- Downloads 0
Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification
"AIM: To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema (CME) after phacoemulsification. METHODS: Group sequential obs...
Comment on “Predictors of short-term outcomes related to central subfield foveal thickness after intravitreal bevacizumab for macular edema due to central retinal vein occlusion”
Comment and Response
A Chinese family with Axenfeld-Rieger syndrome: report of the clinical and genetic findings
"AIM: To describe a Chinese family affected by a severe form of Axenfeld-Rieger syndrome (ARS) and characterize the molecular defect in PITX2 in the family. METHODS: Patients presented with typical ARS from a Chinese fam...
Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs
"AIM: To study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on c...
Vessel density in OCT angiography permits differentiation between normal and glaucomatous optic nerve heads
"AIM: To evaluate whether optical coherence tomography angiography (OCTA) can detect altered vessel density (VD) at the optic nerve head (ONH) in glaucoma patients. Special attention is paid to the accuracy of the OCTA t...