Differentiating Crohn’s Disease from Ulcerative Colitis - New Factors
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 18, Issue 4
Abstract
The characteristics of inflammatory bowel diseases (IBD) are often ambiguous. The information obtained may deepen the cur-rent state of knowledge about ulcerative colitis and Crohn’s disease. For this reason, finding the optimal classifier to support further analysis of medical data is a factor determining the correct allocation of a patient to a given disease entity. The data were subjected to selection methods to find symptoms differing in the two analyzed groups. Then, the extracted variables were introduced into the classifier in order to build the classification model. Factors that were significantly different between patients with Crohn’s disease and ulcerative colitis were found. The built-in system with very high efficiency is able to predict to which group of diseases belongs new, undiagnosed patient (sensitivity 100%, specificity 98.48%). The constructed model can be an excellent method of assisting physicians in making decisions. Importantly, the system should be checked in a variety of balanced research groups to confirm its effectiveness.Crohn’s disease (CD) and ulcerative colitis (UC) have been known to physicians for decades. Unfortunately, so far there are many unknowns regarding CD and UC. There are numerous descriptions of clinical cases, different locations of disease symptoms, and descriptions of symptoms located both in the gastrointestinal tract and symptoms accompanying the disease. All this information sheds light on the etiology of inflammatory bowel disease (IBD) do not completely resolve their complexity. An analysis of the literature presented in the work indicates that the characteristics of diseases are often unambiguous. This contributes to the fact that IBD diagnostics are often difficult and create many problems [1-3]. Despite many years of research on inflammatory bowel diseases, they are still of interest to scientists today. Nonspecific inflammatory bowel disease is a term referring to chronic and recurrent gastrointestinal disease. A number of clinical symptoms distinguish between CD and UC, whose clinical picture is relatively diverse. However, in many cases the diagnosis is not straightforward, which contributes to the interest of researchers worldwide in the disorders under discussion. The inflammatory changes in the course of UC are continuous and limited to the mucous membrane of the large intestine. UC-related inflammation usually involves the mucosa and submucosa usually begins in the rectum and spread proximal to the colon. The affected tissue is swollen, with the presence of erosions and ulcers, which lead to spontaneous bleeding.In most cases, UC initially occurs smoothly, with worsening symptoms within a few weeks. It happens, however, that the disease begins suddenly and goes very quickly. In such cases, due to the lack of the effect of conservative treatment, surgical treatment is already implemented in the early stages of the disease. However, in most cases, after the first shot of the disease, it goes into remission, after which it becomes more severe again. Such continuous conditions of illness and remission may last even several dozen years [1,2]. In the case of CD, the condition most often includes the small intestine and caecum, which accounts for 40% of cases, only small intestine (30% of patients) and only large intestine (25% of cases). In situations where only the large intestine is covered, two forms of the disease are recognized. The first one concerns about two thirds of cases and consists in taking the entire length of the large intestine with the disease state, while the second involves the occurrence of staple changes, which is one third of the diagnoses. Isolated inflammation of the anus or upper gastrointestinal tract is the least common form and occurs only in less than 4% of patients [3,4].
Authors and Affiliations
Anna Kasperczuk, Agnieszka Dardzinska
Keywords
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- EP ID EP622633
- DOI 10.26717/BJSTR.2019.18.003198
- Views 158
- Downloads 0
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