Diffusion weighted (DW) MRI in assessment of renal function - a preliminary study to determine the Apparent Diffusion Coefficient (ADC) values of kidneys with normal function
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 12
Abstract
Aim: To determine the ADC values of kidneys in patients with normal serum creatinine values as an initial step to investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal function in comparison with serum markers of renal function. Materials and Methods: MR imaging is performed on 1.5 Tesla MR machine (Siemens) Diffusion weighted images are obtained at b values 0, 50. 400 and 800. Using automated ROI delineation methods ADC values are measured in the upper pole, interpolar region and lower pole of both kidneys. The mean ADC values were recorded for each kidney for each patient is recorded. The patients selected for this study had normal values for serum markers of renal function. Results: The ADC value for renal parenchyma varied from 1.697x 10-3 mm 2 /s to 1.948x10-3 mm 2 /s with a mean ADC value of kidneys ranging from 1.730x10-3 mm 2 /s to 1.885x10-3 mm 2 /s Conclusion: Diffusion weighted MR imaging of the kidney can be useful imaging modality in the early determination of renal parenchymal disease especially with unilateral dysfunction. ADC values may predict abnormality earlier than serum markers of renal function.
Authors and Affiliations
Dr Bindu R Kumar
Keywords
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