Digestive Disorders in Children with Antibiotic-Associated Diarrhea
Journal Title: Здоров`я дитини - Year 2016, Vol 5, Issue 73
Abstract
Introduction. The most notable problem of the widespread use of antibiotics is the changes in microbial ecology, imbalance of intestinal biocenosis, the appearance of antibiotic-resistant strains of microorganisms with pathogenic properties and due to this the pathological changes in the intestine that cause symptoms of digestive disorders in patients with antibiotic-associated diarrhea. Objective. To identify the symptoms of malabsorption in order to improve early diagnosis of antibiotic-associated diarrhea in children. Materials and methods. The object of the study were 116 patients treated with antibiotics, aged 6 months to 18 years. The examination of children included clinical, biochemical, bacteriological, immunoenzyme, immunochromatographic, instrumental, mathematical methods. Results. In the development of diarrhea in patients with negative test on clostridial toxins, such cases were qualified as idiopathic antibiotic-associated diarrhea, with positive — like intestinal Clostridium difficile infection. The study revealed significant differences in scatological indices between the children with acute idiopathic and antibiotic-associated diarrhea caused by clostridial infection. During microscopic and biochemical studies of feces, we have revealed symptomatic signs of impaired digestion and absorption of fats and carbohydrates, which manifested by clinical symptoms of malabsorption. All children with antibiotic-associated diarrhea are characterized by increased concentrations of carbohydrates in feces. Signs of digestive disorders with the development of malabsorption of lipids were detected n children with antibiotic-associated diarrhea, primarily caused by Clostridium difficile infection. Conclusions. Maldigestion and lipid and carbohydrate absorption, as well as symptoms of inflammation in the intestines (leukocytes, occult blood, mucus) are the markers of antibiotic-associated diarrhea and can be used for its early diagnosis, including in the case of Clostridium difficile infection.
Authors and Affiliations
O. A. Radutna, N. V. Kysyma
Keywords
Related Articles
- EP ID EP193200
- DOI 10.22141/2224-0551.5.1.73.1.2016.78955
- Views 111
- Downloads 0
Liver Damage in Systemic Lupus Erythematosus in Adolescents
The objective of the study was to investigate the state of the liver in adolescents with systemic lupus erythematosus (SLE). As a result of examination of 48 patients with SLE aged 12–18 years, there were established inc...
About Insipidus Syndrome in Pediatric Practice
The article presents the data on the etiology, pathogenesis, clinical picture and differential diagnosis of insipidus syndrome. The own clinical observation of nephrogenic diabetes insipidus in 17-year-old boy is describ...
Calculated estimates of daily energy expenditure as a basis for the substantiation of nutrition standards for young athletes
Background. Features of daily energy expenditure as an indicator of the level of loads and the basis for scientific substantiation of nutrition standards for young athletes — students of physical training schools — remai...
Correction of Asthenoneurotic Manifestations in Children with Primary Hypertension on the Background of Noophen Administration
The article deals with the use of the drug Noophen in the combination treatment of children with psycho-vegetative syndrome and labile hypertension. Consequently, the study found that Noophen in combination with non-drug...
Food Allergy as a Preformation Factor For Bronchial Asthma Diagnosis in Children
There was reviewed literature data on development and diagnosis of food allergy in children with bronchial asthma to optimization remedial rehabilitation measures.