Digital Pressurized Metered-dose Inhalers Define Adherence, Prevents Pseudo adherence In Obstructive Airway Disease Management!
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 10
Abstract
Aerosol therapy and OAD: Inhalers play a crucial role in the management of patients with obstructive airway disease (OAD), and it is being recognized that the choice of the inhalation device appears to be as important as that of the drug molecule. Aerosol therapy in OAD management has undergone renaissance with the wide availability of several drug delivery platforms including dry powder inhaler, pressurized metered-dose inhaler (pMDI), soft mist inhalers, and portable vibrating mesh nebulizers. The aerosol dynamics allows targeted drug delivery while avoiding the systemic side effects, first-pass metabolism at 1/10th the dosage under controlled settings without compromising on the quick therapeutic action in most of these cases. Since OAD remains progressive disease with persistent or diurnal symptoms due to divergent and varied pathobiologic or overplaying risk factors, choice of inhaler therapy in most of these cases remains a clinical challenge. Notwithstanding the clinical challenges of actuator and breath (inhalation) coordination in pMDIs, they have remained the primary choice of therapy in most cases of progressive or recurrent exacerbations who have relatively low inspiratory flow rates (<30 L/min).[1] However, nonadherence rates for long-term inhaler therapy among adults are estimated to exceed 50%. Nonadherence is associated with unfavorable clinical outcomes and diminished quality of life. Lack of a dose counter makes determining the number of remaining doses in an MDI problematic. The addition of an simple, accurate, and reliable digital dose counter to an inhaler can improve patient satisfaction.
Authors and Affiliations
Deepak Talwar, Prashant Katke, Krishnaprasad Korukonda
Keywords
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