Digoxin Levels and It’s Stability in Different Blood Collection Tubes
Journal Title: Journal of Academic Research in Medicine - Year 2020, Vol 10, Issue 2
Abstract
Objective: Digoxin is monitored because of its narrow range of therapeutic doses and risk of toxicity. Thus, we aimed to evaluate the effect of different blood collection tubes on digoxin levels and its stability. Methods: Samples from 30 volunteers who received digoxin therapy were collected in 5 different tubes: no additive and gel-free glass tube (Z-tube) (reference tube), clot-activator tubes containing gel (Vacusera), clot-activator tubes containing gel (serum separator tube), barrier-free lithium heparinized tube (LiH), and new lithium heparinized tube with a barrier (Barricor). Digoxin levels in tubes were analyzed at 0 and 48 hours (h). Results: No statistical difference was found between 0 and 48 h results in other tubes, except for LiH, and the difference in LiH was also not clinically significant. Digoxin levels in other tubes were not statistically different according to the reference tube, except for Barricor. The digoxin level in Barricor was clinically significantly higher than that in the reference tube. Although a strong correlation was found in the digoxin level between Barricor and Z-tubes, a proportional increase in digoxin level in Barricor was determined. Conclusion: The digoxin levels in the tubes may be used interchangeably, except for Barricor. The reliability and accuracy of digoxin levels may be increased by the identification of a new therapeutic range for Barricor.
Authors and Affiliations
Fatma Demet Arslan, İnanç Karakoyun, Banu İşbilen Başok, Hatice Solmaz, Merve Zeytinli Aksit, Anıl Baysoy, Can Duman
Keywords
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