Diminazene aceturate-concentrations in tissues of dogs co-treated with oxtetracycline long acting
Journal Title: Journal of Sustainable Veterinary & Allied Sciences - Year 2021, Vol 1, Issue 1
Abstract
Diminizene aceturate (DA) is the drug of choice for treating Canine Trypanosomosis and Canine Babesiosis in many countries of the world. However, co-administration of the drug with long acting Oxytetracycline (OXY-LA) has been associated with nervous signs suggestive of its toxicity, in treated dogs, even at the normal dose. To investigate what causes this toxicity, fourteen Nigerian indigenous dogs were randomly selected into two groups that comprised six dogs each and the remaining untreated two dogs were used for preparation of tissue standards. One group was treated with DA (3.5mg/kg) alone while the other was, additionally, treated with OXY-LA, 10 minutes post treatment (PT) with DA. Two dogs from each group were sacrificed at 240, 360 and 480 hours, PT and their livers, brains, kidneys, hearts and skeletal muscles were harvested and assayed for DA. Mean DA-concentrations in brains of the DA-OXY-LA group (19.71± 1.31a; 15.86± 2.96a; 9.11± 3.31a) were higher (P≤ 0.05) than 1.39 ± 0.45b; 1.05± 0.29b; 0.71 ± 0.30b of the DA-alone group at 240, 360 and 480 hours, PT, respectively. Also, mean-DA concentration in kidneys (8.00 ±0.46a) of the DA-OXY-LA group was significantly (P≤ 0.05) higher than 3.76±0.32b of the DA-alone group at 360 hours PT. These results suggest that OXY-LA enhances DA-accumulation in the brain and reduces its kidney-elimination, thus making the normal dose to act as overdose, which causes the nervous signs often manifested by treated dogs.
Authors and Affiliations
Onyeachonam, F. O. , Onyeyili, P. A. , Saganuwan, A. S. & Agbo, O. J.
Keywords
Related Articles
- EP ID EP702928
- DOI 10.54328/covm/josvas.2021.010a
- Views 93
- Downloads 0
Significance of graded doses of aqueous seed extract of Moringa oleifera (L) on live body weight, gonadal, extragonadal dimensions and sperm reserves of Yankasa rams
The aim of the study was to investigate the effects of Moringa oleifera aqueous seed extract on live body weight, gonadal and extragonadal dimensions and sperm reserves of Yankasa rams. Twenty five apparently healthy Yan...
Anthelmintic activities of Momordica charantia (bitter melon) on helminths: a review.
Medicinal plants and their products continue to be an important therapeutic aid for alleviating ailments and maintenance of human and animal health. The significance of plants in medicine remains a greater relevance with...
Prevalence of trypanosomes in large and small ruminants in Abia and Rivers State Nigeria
This study investigated the prevalence of trypanosomes in ruminants in Abia and Rivers states, Nigeria by evaluating the trypanosomes parasitaemic profiles of the cattle, sheep and goats studied. Fifty adult cattle (N’da...
Effect of season, age, and sex on haematology and serum biochemistry of sport horses
Blood is an important medium for assessing the health status of individual animals: variations in blood parameters of animals are due to several factors such as altitude, feeding level, age, sex, breed, disease, seasonal...
Effect of activated charcoal on different aspects of poultry performance: a short review
This paper presents a short review of the effects of activated charcoal (AC) on different aspects of poultry performance. Activated charcoal is a solid, porous, tasteless and black carbonaceous material prepared from a v...