Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection
Journal Title: Journal of Acute Disease - Year 2018, Vol 7, Issue 1
Abstract
Objective: To investigate the improved antitrypanocidal activity and toxicity of diminazene aceturate modified Nano drug in experimental rats. Methods: Aqueous leaf extract of Hyptis suaveolens was used to reduce gold tetrachloride to its nanoparticle size and this was characterized and formulates with naturally synthesized polyhydroxybutyrateas a Nano carrier. A total of thirty (30) albino rats were group into 6 (A-F) of 5 rats each & infected intraperitoneally with 0.2 mL of the inoculum containing about 1伊103 Trypanosoma brucei brucei parasites per 0.2 mL of blood. Groups A and B were treated with 3 and 6 minutes released orange PHB, Groups C and D were treated with 15 and 30 minutes released mango PHB formulated tablet while Groups E and F were negative (untreated) and standard drug (Dininazene aceturare) respectively. Results: The free drug and modified orange synthesized polyhydroxy butyrate shows antitrypanocidal activities by reducing the replicating rate of the parasite as compared to infect untreated. While the modified- mango synthesized shows increasing order of replication. There were significant increases in all the haematological parameter evaluated in the infected treated groups compared to infect untreated. But no significant difference (P<0.05) observed in the Catalase activity in the serum and liver of all the groups whereas, the modified orange synthesized shows significant decrease in other enzymes activities evaluated when compared with the free drug, mango synthesized and the infected untreated groups. Conclusion: Orange synthesized modified diminazene aceturate show efficacy as free drug with limited toxicity that can enhance the therapeutic.
Authors and Affiliations
Oluwatosin Kudirat Shittu, Shaba Yisa Aaron, Mariam Damilola Oladuntoye, Bashir Lawal
Keywords
Related Articles
- EP ID EP282511
- DOI 10.4103/2221-6189.228876
- Views 130
- Downloads 0
Acute cholecystitis and helminthic infestation
Acute cholecystitis is an important acute medical problem, so acute disorder of the gall bladder requires good clinical management. There are several etiologies of acute cholecystitis. Although it is not common, helminth...
Evaluation of the primary anastomosis side effects in patients with sigmoid volvulus in Imam Hossein and Firoozgar Hospitals in 2014-2015
Objective: The term volvulus is derived from a Latin word volvere means to turn, twist which is mainly referred to as twisting of sigmoid and can lead to ischemia and gangrene. Nowadays, it is the 3rd most common reason...
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran
Objective: Since pre-transfusion screening for Toxoplasma gondii is not performed on blood packs, thalassemia patients are susceptible to acquiring toxoplasmosis; thus, the aim of this study was to evaluate the seropreva...
Necrotizing fasciitis following mild trauma in a patient with mellitus diabetes: a case report
Rationale: Necrotizing fasciitis is a rare infection of fascia tissues. It progresses quickly and has high morbidity and mortality. In this study, we aimed to explore a case of necrotizing fasciitis in a diabetic patient...
Conservative approach in drilling-cutting tool injuries
Objective: To prevent unnecessary laparotomies by evaluating the effectiveness of conservative approach in abdominal trauma cases due to drilling-cutting instruments. Methods: Demographic data, effected region of the bod...