Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach

Abstract

Background: Dipeptidyl peptidase-IV (DDP-IV) Inhibitors may represent single anti-diabetic drugs, the multiple actions of which may translate into demonstrable therapeutic benefits in diabetes. The marketed synthetic DPP-IV Inhibitors are expensive drugs and have been reported to cause unacceptable adverse effects such as pancreatitis, angioedema, thyroid and pancreatic cancers. In this scenario, research to identify DPP-IV Inhibitors from alternative sources is desirable.

Authors and Affiliations

Mohanty Ipseeta Ray, Kumar Selvaa, Suman Rajesh

Keywords

Related Articles

The Importance of Risk Stratification and Management of Newborn Babies of Women with a History of Graves’ disease

Thyroid hormones are important for early brain development. During pregnancy, both maternal and foetal thyroid hormones contribute to foetal brain development. Maternal Graves’ can lead to transplacental transfer of anti...

Efficacies of Eruca sativa and Raphanus sativus Seeds’ Oils in Streptozotocin-Induced Diabetic Rats

Objective: The study was planned to investigate the effect of Eruca sativa seeds’ oil (ESSO) and Raphanus sativus seeds’ oil (RSSO) on impaired glucose tolerance, lipid profile and oxidative stress in streptozotocin-indu...

Clinical Aspects of C-Type Natriuretic Peptide on the Cardiovascular System

C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological ac...

60-Year-Old Man with Pheochromocytoma and Clinical Picture of Depression

Introduction: Pheochromocytoma is an adrenal gland tumour, which usually produces catecholamines. The classical triad of clinical symptoms consists of palpitations, headaches and profuse sweating. Other symptoms include:...

Closing the Mortality Gap in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: Implications of a Clinical Decision Support App

Diabetes is a major public health issue affecting millions of people in the United States and worldwide. In the United States alone, about 30.3 million people (9.4% of the population) have diabetes [1]. Worldwide, a stag...

Download PDF file
  • EP ID EP542456
  • DOI 10.17352/ijcem.000024
  • Views 96
  • Downloads 0

How To Cite

Mohanty Ipseeta Ray, Kumar Selvaa, Suman Rajesh (2017). Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach. International Journal of Clinical Endocrinology and Metabolism, 3(1), 18-22. https://europub.co.uk/articles/-A-542456