DIPNECH – a preneoplastic lesion or a separate biological entity?
Journal Title: Progress in Health Sciences - Year 2013, Vol 3, Issue 2
Abstract
Introduction: DIPNECH is a very rare condition with under 100 cases reported in the scientific literature worldwide. The new WHO classification of lung tumors considers it as a preneoplastic condition, leading to further growth of pulmonary carcinoid tumors. Prior to that, proliferating neuroendocrine, or NE cells in the respiratory epithelium develop into tumorlets – lesions less than 5mm in the largest size, visible in diagnostic imaging as round shadows and sometimes mistake for metastases of a tumor of unknown origin. Purpose: The goal here is to strongly recommend the foundation of a world wide web (www) based portal with clinical information about DIPNECH, also, if possible, containing reports of all the cases ever diagnosed. This will create an easily accessible source of information, which could increase the rate of diagnosis for this condition. Thanks to further possibilities of scientific exchange and development such as a database could become a vast archive of pulmonary preneoplastic lesions with possible clues to understanding mechanisms of carcinogenesis. Discussion: It is yet unclear, if DIPNECH could be a predecessor of other neuroendocrine tumors, at least being one of their possible origins, or is the growth of NE cells around the primary neuroendocrine tumor a reaction for airway obstruction and hypoxia. Conclusion: According to information gathered through electronic search, further scientific investigation of DIPNECH might be very helpful in understanding carcinogenesis in lung.
Authors and Affiliations
T Dawidziuk, E Sawicka, L Chyczewski
Keywords
Related Articles
- EP ID EP75373
- DOI -
- Views 91
- Downloads 0
Wombs for rent, outsoursed pregnancies, baby farms - ethics and surrogate motherhood
The history of surrogacy is composed of cases of happy solving family problems, but also of conflicts and lawsuits concerning a child and his welfare. In modern times it became the next to adoptions additional possibilit...
The influence of carotenoid and chlorophyll content on the oxidative processes in the selected vegetable oils
Purpose: More than 100 plant species have been classified as oil products, but only a few of them are used in industrial production. In the available literature, there are no studies that would describe the relationship...
Volumetric magnetic resonance imaging of gastrocnemius muscle in a patient with facioscapulohumeral dystrophy
Introduction: Magnetic resonance imaging (MRI) is a nonradiographic, non-invasive method to visualize and quantify muscle cross-sectional areas and volumes. Purpose: To evaluate a gastrocnemius muscle volume in a 15-ye...
Uncovering supplementary information from questionnaire inquiry on physical ability with the aim to develop psycho-educational intervention: An example of a study using the SF-36 questionnaire among convalescents after acute pancreatitis
Purpose: The aim of this paper was to complete a series of our own reports on health-related outcomes of rehabilitation following successful clinical therapy in Poland, based on data from a questionnaire survey using the...
The quality of life in parents raising children with an autism spectrum disorder from Poland, Belarus and France
Purpose: To assess the health-related quality of life (HRQL) in parents of children with autism spectrum disorder (ASD). Materials and methods: The sample consisted of 83 families with children with ASD, including 30 fam...