Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 4
Abstract
Thiazolidinedione (1) was used as a key intermediate for the synthesis of many therapeutic anti-diabetic molecule. Thus, Thiazolidinedione (1) was refluxed with aromatic aldehydes and phenol derivatives to afforded aryldine derivative (3). Moreover, the stereochemistry for compound 3 was discussed using Hartree-Fock theory geometries, and have been optimized at HF with 6-311G level of theory. The HOMO-LUMO energy gap of studied systems has been discussed. The molecular docking simulations into the active site of ALR2 were performed, and showed that, the compound 3 more suitable inhibitor against ALR2 and can used as anti- diabetic drug.
Authors and Affiliations
A. A. Elhenawy, Mahmoud M. Abdel All, Abd aziz A. Alomri
Keywords
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- EP ID EP652728
- DOI 10.24297/jac.v10i4.895
- Views 155
- Downloads 0
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