Discrepancy of Nerve Cells to Form Ataxia, a Rare Neurological Disease, Intimated With Sub Population of Regenerative Cells to Amend Flaws
Journal Title: Journal of Regenerative Biology and Medicine - Year 2020, Vol 2, Issue 5
Abstract
Discrepant results due to lack of phenotype-specific species to species relevance to pharmacological results from in vitro cell testing cause inappropriate approaches to treatments to rare conditions in the brain. One such condition is Friedrich Ataxia. The prime focus is on this extreme condition, a neurodegenerative condition that sets precedence for clinical trials. Compounds such as nicotinamide and resveratrol were selected and used in the treatment of Ataxia, the condition shows no improvement. These compounds contracted various responses in iPSC derived neuron generation and more discoverable approach to drug delivery system in vitro conditions. The cell types from iPSC were considered nonrelevant for the disease derived from fibroblasts and more relevant to disease derived from neurons differentiated iPSC cells. This above illustrates the value of utilizing human iPSC cells to improve drug discovery and cure. The over the reacting theory of human iPSC cells are advanced further to discover the potent application of stem cells and further discuss the feasibility of transplantation of Friedrich Ataxia(FA) patients bone marrow-derived mesenchymal stem cells to discover the GAA expansion and reduced FXN and mRNA expression. There is scope for discussion for the assessment of the proliferative ability of pluripotency of FR from bone marrow. The characteristics of bone marrow in vitro differentiation have two types of cells, peripheral neurons, and cardiomyocytes. Also, this chapter leads to series of discussions on the need for testing applications on bone marrow mesenchymal stem cells, mutated gene correction that will play a critical role in gene-based cell therapy, and human artificial chromosomes intact with FXN genes differentiated into neurons or cardiomyocytes.
Authors and Affiliations
Prithiv Kumar KR1, Albert Alukal2
Keywords
Related Articles
- EP ID EP707347
- DOI https://doi.org/10.37191/Mapsci-2582-385X-2(5)-044
- Views 52
- Downloads 0
Antler Stem Cells Sustain Regenerative Wound Healing in Deer and in Rats
Deer antlers are unique mammalian appendages in that they can fully regenerate following loss from their pedicles (permanent bony protuberances). Antler regeneration starts from regenerative wound healing on top of a ped...
The COVID-19 Pandemic and its Impact on Knowledge, Attitude, and Practices Among Dental Students in Davanagere city, Karnataka: A Cross-Sectional Survey
The spread of viral disease in community and its occurrence among healthcare workers is important evidence of person-to-person transition. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared as a pa...
COVID 19: Camostat and the Role of Serine Protease Entry Inhibitor TMPRSS2
According to the latest research, the novel coronavirus uses the protein angiotensin-converting enzyme 2 (ACE-2) as a receptor for docking to the host cell. Essential for entry is the priming of the spike (S) protein of...
SARS-CoV-2 / COVID-19 and its Implications in the Development of Osteonecrosis
Introduction: The pathogeny of COVID-19 has several repercussions marked by immunological changes, hypercoagulability, ischemic phenomena, the need to use high doses of corticosteroids, factors directly linked to the dev...
Preliminary Results of Vitamin D3 Application Combined With Anisodamine in the Treatment of Alopecia Areata in Children
Alopecia areata is a form of inflammatory hair loss that has been known for a long time, but its cause is largely unexplored. It is characterized by the patient's hair falling out in a circular pattern, which is why this...