Disease-Modifying Drug Possibly Linked to Placental Insuffciency Severe placental complications in a pregnant woman with multiple sclerosis
Journal Title: Sultan Qaboos University Medical Journal - Year 2016, Vol 16, Issue 3
Abstract
Disease-modifying drugs (DMDs) such as interferon (IFN)-β and glatiramer acetate are often prescribed to slow disability progression in patients with multiple sclerosis (MS). However, adverse pregnancy outcomes have been reported with these medications. We report the rare occurrence of severe placental complications in a 30-yearold pregnant woman with MS who continued to take IFN-β during her frst trimester. She presented at the Tawam Hospital, Al Ain, United Arab Emirates, in 2013 with early-onset fetal growth restriction. At 30 gestational weeks, she developed severe pre-eclampsia. Te baby was delivered via emergency Caesarean section and was discharged at the age of two months. Continuation of IFN-β during pregnancy may have contributed to the development of placental insufciency in this patient. Increased education regarding the risks of DMDs for pregnant patients with MS is very important to ensure successful pregnancy outcomes.
Authors and Affiliations
Sultan M. Salahudheen| Department of Pharmacy, Sheikh Zayed Hospital, Abu Dhabi, United Arab Emirates, Muzibunnisa A. Begam| Department of Obstetrics & Gynaecology, Tawam Hospital, Al Ain, United Arab Emirates
Keywords
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