Disease-Modifying Drug Possibly Linked to Placental Insuffciency Severe placental complications in a pregnant woman with multiple sclerosis
Journal Title: Sultan Qaboos University Medical Journal - Year 2016, Vol 16, Issue 3
Abstract
Disease-modifying drugs (DMDs) such as interferon (IFN)-β and glatiramer acetate are often prescribed to slow disability progression in patients with multiple sclerosis (MS). However, adverse pregnancy outcomes have been reported with these medications. We report the rare occurrence of severe placental complications in a 30-yearold pregnant woman with MS who continued to take IFN-β during her frst trimester. She presented at the Tawam Hospital, Al Ain, United Arab Emirates, in 2013 with early-onset fetal growth restriction. At 30 gestational weeks, she developed severe pre-eclampsia. Te baby was delivered via emergency Caesarean section and was discharged at the age of two months. Continuation of IFN-β during pregnancy may have contributed to the development of placental insufciency in this patient. Increased education regarding the risks of DMDs for pregnant patients with MS is very important to ensure successful pregnancy outcomes.
Authors and Affiliations
Sultan M. Salahudheen| Department of Pharmacy, Sheikh Zayed Hospital, Abu Dhabi, United Arab Emirates, Muzibunnisa A. Begam| Department of Obstetrics & Gynaecology, Tawam Hospital, Al Ain, United Arab Emirates
Keywords
Related Articles
- EP ID EP14699
- DOI -
- Views 302
- Downloads 14
Health Consequences of Iodine Deficiency
Iodine Deficiency Disorders (IDD) are one of the biggest worldwide public health problem of today. Teir effect is hidden and profoundly affects the quality of human life. Iodine deficiency occurs when the soil is poor i...
Incentives for Better Performance in Health Care
Incentives for better performance in health care have several modes and methods. Tey are designed to motivate and encourage people to perform well and improve their outcomes. Tey may include monetary or non-monetary in...
Ankle Brachial Index in Children with Steroid-Resistant Nephrotic Syndrome
Objectives: Tis study aimed to assess the ankle brachial index (ABI) as a predictor of peripheral arterial diseases (PAD) in children with steroid-resistant nephrotic syndrome (NS). Methods: Twenty children (11 males a...
Sporadic Lateral Ventricular Hemangioblastoma presenting with Intraventricular and Subarachnoid Haemorrhage
Intraventricular hemangioblastoma (HB) is very rare; few cases of intraventricular HB have been reported in the literature, either sporadically or in association with von Hippel-Lindau disease. Furthermore, the inciden...
Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers Retrospective cohort study
Objectives: Saliva contains alkaline phosphatase (ALP)—a key intracellular enzyme related to destructive processes and cellular damage—and has buffering capacity (BC) against acids due to the presence of bicarbona...