Disposition kinetic and bioavailability of florfenicol in buffalo calves
Journal Title: Journal of Veterinary Medical Research - Year 2005, Vol 15, Issue 1
Abstract
The Pharmacokinetics of florfenicol was studied in buffalo calves following single intravenous and intramuscular administration of 20 mg kg-1 b.wt. Florfenicol concentration in both serum and urine were determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism. After intravenous injection the serum florfenicol concentration time course obeys two-compartment open model with distribution (t0.5 ()) and elimination (t0.5 ()) half lives of 0.381 ± 0.004 and 2.89 + 0.263 h., respectively. Total body clearance (CLB) and steady state volume of distribution (Vdss) were 3.6 ± 0.30 ml kg-1 min-1 and 1.70 ± 0.010 l kg-1., respectively. After intramuscular administration the observed mean peak serum concentration (Cmax) was 2.32 ± 0.052 3g ml-1 achieved after maximum time (Tmax) of one hour postinjection. The systemic bioavailability after intramuscular administration was 27.43 % and the plasma protein binding was 13.5 %.
Authors and Affiliations
A. A. M. El- Gendy1; M. A. Tohamy1; M. Ismail2 1Pharmacology Department Faculty of Veterinary Medecine Beni-suef University, Beni-suef, Egypt 2Pharmacology Department Faculty of Veterinary Medecine Cairo University, Cairo, Egypt
Keywords
Related Articles
- EP ID EP682717
- DOI -
- Views 224
- Downloads 0
Beneficial roles of boron supplementation in the ration of rams on productive activity and semen quality
The aim of this study is to determine the effects of boron supplementation in ration of rams on their productive activity and semen quality. For that purpose, twelve rams were divided into two groups (6 rams/ each). Rams...
Phenotypic and genotypic characterization of methicillin resistant Staphylococcus aureus
Food contaminated with multiple antibiotic-resistant S.aureus can be a major threat to the public health. The purpose of this study was to isolate S.aureus from different food sources, determine their antimicrobial susce...
EFFECT OF SOME PLANT OILS ON REPRODUCTIVE ACTIVITIES IN FEMALE ALBINO RATS
The present study aimed to determine the effect of adding plant oils; extra virgin olive oil (EVOO), sunflower and soybean to animal feed on serum estradiol (E2) and progesterone (P4) levels, histological structure of ov...
Antimicrobial and immunological studies on Pasteurella multocida and Mannheimia haemolytica recovered from calves affected with respiratory manifestations
Pneumonic pasteurellosis is the main cause of severe respiratory tract infections in calves and causing great economic losses. The objective of this research was to study the antimicrobial susceptibility of P. multocida...
Detection of bovine herpesvirus type 1 and bovine ephemeral fever virus antigens in cattle lymph nodes using three immunological assays
Lymph nodes (Ln) are the preferred samples for virus isolation and detection. In the present study, carcass and visceral Ln of apparently healthy cattle were screened for the presence of bovine herpes virus type 1 (BHV-...