Disruption of Disulfide Bonds of Insulin Receptor as a Cause of Insulin Resistance in DM2
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 11, Issue 3
Abstract
Many theories have been put forward to explain insulin resistance in DM2. The cause of insulin resistance still remained an enigma till date. Defect in insulin signaling pathway is one such possibility considered for insulin resistance in DM2. For insulin signal transduction to occur downstream, the insulin receptor should be in tetrameric, holo-enzyme form so that the conformational changes and auto-phosphorylation steps take place. A prerequisite to this is, linkage of the two α-sub-units and α,β -sub-units of the pair of the dimers by disulfide bonds. Without this, the receptor is in the α,β dimer half-enzyme form, devoid of any binding affinity to the ligand or auto- phosphorylating activity. The article intends to explore, disruption of the disulfide bond formation, as a possible cause of insulin resistance in DM2.
Authors and Affiliations
A. S. V. Prasad
Keywords
Related Articles
- EP ID EP351212
- DOI 10.9734/IJBCRR/2016/24489
- Views 131
- Downloads 0
Assessment of Some Biochemical Oxidative Stress Markers in Type II Diabetics and Non-diabetics with Chronic Periodontitis
Aims: Comparative assessment of some biochemical oxidative stress markers in Type II diabetics and non-diabetics with chronic periodontitis. Study Design: The cross sectional study groups were clinically evaluated and th...
Evaluation of the in vitro Antioxidant Activities of Leaves Extracts of Persea americana and Ficus exasperata Collected from Akure, Nigeria
Aim: The study examined the phytochemical composition and antioxidant potentials of leaves extracts of Persea americana and Ficus exasperata obtained from Akure, Ondo state. Study Design: Methanol and acetone were used...
Evaluation of Nephroprotective Activity of Aqueous and Hydroethanolic Extracts of Trema guineensis Leaves (Ulmaceae) against Gentamicin-Induced Nephrotoxicity in Rats
Aims: The present study investigated the potential nephroprotective activity of aqueous and hydroethanolic extracts of Trema guineensis leaves (Ulmaceae) and determined the most active extract in rat. Study Design: Trema...
Purification and Characterization of a Small Chito-specific Lectin from Datura innoxia Seeds Possessing Anti-microbial Properties
Aims: To purify and characterize the smallest lectin from Datura innoxia (DiL9) and to evaluate its antimicrobial application potential. Study Design: Protein purification and characterization using biochemical and bioph...
Some Indices of Carbohydrate Metabolism in Rats Maintained on Heat-treated Vigna unguiculata Husk
The high cost of feed ingredients such as corn is one of the most important factors in livestock production. If agricultural by-products such as Vigna unguiculata husk could replace corn starch in animal feed, the cost o...