Dissecting Molecular Pathways and Intricate Mechanisms Underpinning Antibiotic Resistance in Gram-Negative Bacteria: An Exhaustive and Integrative Review
Journal Title: International Journal of Health & Medical Research - Year 2024, Vol 3, Issue 09
Abstract
Concern for antibiotic resistance in Gram negative bacteria is fast becoming a global issue due to the reduction of effectiveness of current drugs. This review deconstructs the material in a logical, categorized manner, examining the biochemistry of antibiotic resistance mechanisms such as efflux pumps, enzymatic degradation, genetic changes, and the regulation of those changes. Close associated gene transfer, especially the plasmids-mediated resistance, and how biofilms contribute to the survival of bacteria under antibiotic pressure. Present methods of detection and diagnosis are also described with emphasis on the importance of identifying a resistant strain quickly and accurately. Last, we discuss directions for ongoing and future progress in tackling antibiotic resistance, such as new treatments and public health directions. Based on these observations, it is the hope of this review to contribute to the existing literature and initiatives geared towards reversing the escalating problem of antibiotic resistance.
Authors and Affiliations
Nawar Bahaa Abdulsahib, Yasser Ali Hussein, Bilal Husam Jasim,
Keywords
Related Articles
- EP ID EP750599
- DOI 10.58806/ijhmr.2024.v3i09n07
- Views 3
- Downloads 0
Potential Extract of Lerak Fruit (Sapindus Rarak), Pegagan (Centella Asiatica,) Mimba Seed (Azadirachta Indica A.Juss) and Mixing of Third Extract to Motility and Viability of Spermatozoa Guinea Pigs (Cavia Porcellus)
Background: Spermicides are substances that can kill spermatozoa. Spermicide circulating in the community contains Nonoxynol9 which, if used for a long time, can irritate the vaginal mucosa and penis. Indonesia has a var...
Correlation Of Placental Changes With Fetal And Maternal Outcome In Mothers With Hypertensive Disorders Of Pregnancy
Hypertension represents one of the most prevalent complications encountered during pregnancy, significantly contributing to both maternal and perinatal morbidity and mortality. The placenta, acting as a crucial feto-mate...
Computational Identification of Human TGFΒ1 Gene: SNPS and Prediction of Their Effect on Protein Functions of Preeclampsia Patients
Growth factor (TGF-β1) belongs to the superfamily (TGF-β) as it has different roles and functions and participates in various physiological, biological, and pathological processes. The protein (TGF-β1) works to regulate...
The Challenge of Clinical and Surgical Management of An Acute Myocardial Infarction Simultaneously with An Acute Compressive Neurological Syndrome Due to Pituitary Adenoma: A Case Report
The term acute coronary syndrome represents a group of signs and symptoms in a patient who exhibits clinical and/or laboratory evidence of the occurrence of acute myocardial ischemia. This concept encompasses acute myoca...
Etiology of Antisperm Antibodies in Infertile Men: A Review Article
The presence of antisperm antibodies (ASAs) in infertile males is the underlying cause of ‘immune infertility’. The mechanism by which ASAs induce male infertility is not completely comprehended. Immune infertility is ca...